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3D Bioprinting in Conjunction with Bone Marrow Mesenchymal Stem Cells for the Treatment of Bone Defects
Clinical management of bone defects remains a challenge. Currently, the principal therapeutic option is autologous or synthetic bone grafting....
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Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization
Alveolar bone regeneration has been strongly linked to macrophage polarization. M1 macrophages aggravate alveolar bone loss, whereas M2 macrophages...
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Human Bone Marrow Derived-Mesenchymal Stem Cells Treatment for Autoimmune Premature Ovarian Insufficiency
BackgroundPremature ovarian insufficiency (POI) is a relatively common gynecologic endocrine disorder, which is hypogonadism associated with...
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Bone marrow mesenchymal stem cells’ osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?
Skeletal problems are an increasing issue due to the increase in the global aging population. Different statistics reports show that today, the...
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3D Bioprinting in Conjunction with Bone Marrow Mesenchymal Stem Cells for the Treatment of Bone Defects
Clinical management of bone defects remains a challenge. Currently, the principal therapeutic option is autologous or synthetic bone grafting....
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MiR-422a promotes adipogenesis via MeCP2 downregulation in human bone marrow mesenchymal stem cells
Methyl-CpG binding protein 2 (MeCP2) is a ubiquitous transcriptional regulator. The study of this protein has been mainly focused on the central...
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Differentiation of bone marrow mesenchymal stem cells into Leydig-like cells with testicular extract liquid in vitro
Differentiation of Leydig cells plays a key role in male reproductive function. Bone marrow mesenchymal stem cells (BMSCs) have emerged as a...
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A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells
Breast cancer, the most prevalent malignancy in women, often progresses to bone metastases, especially in older individuals. Dormancy, a critical...
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Long noncoding RNA KCNMA1-AS1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the SMAD9 signaling pathway
The human bone marrow mesenchymal stem cells (hBMSCs) undergo intense osteogenic differentiation, a crucial bone formation mechanism. Evidence from...
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Vitamin D supplementation affects bone marrow-derived mesenchymal stem cells differentiation into insulin-producing cells
Background this study was conducted to assess the effects of vitamin D on differentiation of bone marrow- derived mesenchymal stem cells (BM-MSCs)...
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Effect of RNA-binding proteins on osteogenic differentiation of bone marrow mesenchymal stem cells
Tissue regeneration mediated by mesenchymal stem cells (MSCs) is an ideal way to repair bone defects. RNA-binding proteins (RBPs) can affect cell...
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Proliferation-Related Features of the Human Mesenchymal Stem Cells Derived from Palatine Tonsils, Adipose Tissues, and Bone Marrow
Background:Mesenchymal stem cells (MSCs) are widely used in regenerative medicine and cell-based transplantations. However, an in-depth comparison of...
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Generation of complex bone marrow organoids from human induced pluripotent stem cells
The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a method for generating complex BM-like organoids (BMOs) from...
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Substrate topographies modulate the secretory activity of human bone marrow mesenchymal stem cells
BackgroundMesenchymal stem cells (MSCs) secrete a diversity of factors with broad therapeutic potential, yet current culture methods limit potency...
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Role of reactive oxygen species (ROS) in the regulation of adipogenic differentiation of human maxillary/mandibular bone marrow-derived mesenchymal stem cells
BackgroundMaxillary/mandibular bone marrow-derived mesenchymal stem cells (MBMSCs) exhibit a unique property of lower adipogenic potential than other...
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Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials
The aim of the study is to determine the effectiveness of stem cells in scaffolds in the treatment of bone deficits, in regard of bone regeneration,...
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Mesenchymal Stem Cells for Bone and Cartilage Regeneration: State of the Art
Mesenchymal stem cells (MSCs) have essential applications in bone and cartilage regenerative medicine. Undifferentiated MSCs show a high...
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Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue
Pulmonary arterial hypertension (PAH) is a chronic disease thatultimately progresses to right-sided heart failure and death. Erythropoietin (EPO) has...
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Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions
BackgroundOur previous study investigated the levels of soluble growth factors in the conditioned media of bone marrow-derived mesenchymal stem cells...
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Bone marrow derived mesenchymal stem cells therapy for rheumatoid arthritis - a concise review of past ten years
Rheumatoid arthritis is an autoimmune disorder characterized by swelling in synovial joints and erosion of bones. The disease is normally treated...
