Search
Search Results
-
Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice
Novel treatments for muscle wasting are of significant value to patients with disease states that result in muscle weakness, injury recovery after...
-
Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length
Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity. Spaceflight elongates human telomeres in peripheral blood,...
-
CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia
Peripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been...
-
Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice
The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is...
-
The comparison of adipose-derived stromal cells (ADSCs) delivery method in a murine model of hindlimb ischemia
BackgroundAdipose-derived stromal cells (ADSCs) demonstrate ability to promote tissue healing and down-regulate excessive inflammation. ADSCs have...
-
Neurogenesis in the Hippocampus of Mice Exposed to Short-Term Hindlimb Unloading
AbstractLong-term spaceflights and simulated microgravity negatively affect the number of cognitive functions, including memory, learning, spatial...
-
Asperosaponin VI Protects Against Bone Loss Due to Hindlimb Unloading in Skeletally Growing Mice Through Regulating Microbial Dysbiosis Altering the 5-HT Pathway
Osteoporosis is a complex multifactorial disease that can lead to an increased risk of fracture. However, selective and effective osteoporosis drugs...
-
Bradykinin-pretreated Human cardiac-specific c-kit+ Cells Enhance Exosomal miR-3059-5p and Promote Angiogenesis Against Hindlimb Ischemia in mice
BackgroundProtection of cardiac function following myocardial infarction was largely enhanced by bradykinin-pretreated cardiac-specific c-kit + ...
-
The hindlimb of Amphicynodon leptorhynchus from the lower Oligocene of the Quercy Phosphorites (France): Highlight of new climbing adaptations of this early arctoid
The Itardies locality (MP23, 30–31 Ma), in the Quercy Phosphorites (France), has yielded an impressive amount of fossil remains attributed to Amphicyno...
-
Murine Models of Tenotomy-Induced Mechanical Overloading and Tail-Suspension-Induced Mechanical Unloading
Skeletal muscle is a highly plastic tissue that can alter its mass and strength in response to mechanical stimulation, such as overloading and...
-
The Role of Glycogen Synthase Kinase 3 Activity in the Regulation of Mitochondrial Biogenesis in Rat Postural Muscle under Hindlimb Unloading
AbstractMechanical unloading of skeletal muscles is observed under microgravity in astronauts, and in terrestrial conditions with bed rest,...
-
Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading
During duration spaceflight, or after their return to earth, astronauts have often suffered from gait instability and cerebellar ataxia. Here, we use...
-
αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a...
-
Differential bone remodeling mechanism in hindlimb unloaded rats and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse
To determine that differential bone remodeling mechanism (especially Wnt signaling) in hindlimb unloaded rats and hibernating Daurian ground...
-
Characteristics of Bone Marrow Progenitor Cells of C57BL/6N Mice after 30-Day Hindlimb Suspension and 12-Hour Readaptation to Support Loading
AbstractThe functional status of bone marrow (BM) progenitor cells, which provide hematopoiesis and homeostasis of bone tissue, determines many...
-
Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts
Disuse osteoporosis (DO) results from mechanical unloading of weight-bearing bones and causes structural changes that compromise skeletal integrity,...
-
Myogenic progenitor cell transplantation for muscle regeneration following hindlimb ischemia and reperfusion
BackgroundMuscle is severely affected by ischemia/reperfusion injury (IRI). Quiescent satellite cells differentiating into myogenic progenitor cells...
-
Hindlimb unloading causes regional loading-dependent changes in osteocyte inflammatory cytokines that are modulated by exogenous irisin treatment
Disuse-induced bone loss is characterized by alterations in bone turnover. Accruing evidence suggests that osteocytes respond to inflammation and...
-
Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading
AbstractThe effect of HDACs 4 and 5 on the level of atrophy, calpain-1 and titin content, and TTN gene expression in rat soleus after 7-day...
-
Coming to grips with life upside down: how myosin fiber type and metabolic properties of sloth hindlimb muscles contribute to suspensory function
Sloths exhibit almost obligatory suspensory locomotion and posture. These behaviors require both strength and fatigue resistance, although we...
