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High- and Super-Resolution Imaging of Cell-Cell Interfaces
Physical interfaces mediate interactions between multiple types of cells. Despite the importance of such interfaces to the cells’ function, their...
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High-Efficiency Single-Cell Electrical Impedance Spectroscopy
Single-cell impedance measurement is label free and noninvasive in characterizing the electrical properties of single cells. At present, though...
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Live-Cell High-Throughput Screen for Monitoring Autophagy Flux
Autophagy is a cellular process implicated in the renewal of cellular components and the maintenance of cellular hemostasis and therefore associated...
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hcHCR: High-Throughput Single-Cell Imaging of RNA in Human Primary Immune Cells
Functional genomics and chemical screens can identify and characterize novel cellular factors regulating signaling networks and chemical tools to...
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Annotation of the Effect of Chemogenomic Compounds on Cell Health Using High-Content Microscopy in Live-Cell Mode
The characterization of chemogenomic libraries with respect to their general effect on cellular health represents essential data for the annotation...
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Morphological profiling by high-throughput single-cell biophysical fractometry
Complex and irregular cell architecture is known to statistically exhibit fractal geometry, i.e., a pattern resembles a smaller part of itself....
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Cell Type-Specific Analysis for High-throughput Data
Biological samples collected in experiments are often mixtures of different cell types. In the analysis of high-throughput omics data from tissue...
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High-throughput single-cell transcriptomics of bacteria using combinatorial barcoding
Microbial split-pool ligation transcriptomics (microSPLiT) is a high-throughput single-cell RNA sequencing method for bacteria. With four...
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Application of Single-Cell Sequencing on Stem Cell Research
The variation and heterogeneity within cells are the fundamental features of stem cells. Each tissue has a resident stem cell niche compartmentalized...
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sciMET-cap: high-throughput single-cell methylation analysis with a reduced sequencing burden
DNA methylation is a key component of the mammalian epigenome, playing a regulatory role in development, disease, and other processes. Robust,...
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High-Throughput Assembly of Compositionally Controlled 3D Cell Communities for Developmental Engineering
Cell patterning for 3D culture has increased our understanding of how cells interact among themselves and with their environment during tissue...
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SCS: cell segmentation for high-resolution spatial transcriptomics
Spatial transcriptomics promises to greatly improve our understanding of tissue organization and cell–cell interactions. While most current platforms...
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Acoustic tweezers for high-throughput single-cell analysis
Acoustic tweezers provide an effective means for manipulating single cells and particles in a high-throughput, precise, selective and contact-free...
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Production of retroviral vectors in continuous high cell density culture
AbstractRetroviral vectors derived from murine leukemia virus (MLV) are used in somatic gene therapy applications e.g. for genetic modification of...
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p16High senescence restricts cellular plasticity during somatic cell reprogramming
Despite advances in four-factor (4F)-induced reprogramming (4FR) in vitro and in vivo, how 4FR interconnects with senescence remains largely under...
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Building Biomaterials to Mimic 3D Cell–Cell Junctions
Cell–cell interactions typically occur in a 3D context that is distinct from conventional 2D cell-substrate interactions in a Petri dish. Here, we...
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From Cell States to Cell Fates: Control of Cell State Transitions
We examine the coordinated behavior of thousands of genes in cell fate transitions through genome expression as an integrated dynamical system using...
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High-Speed Video Microscopy of Ependymal Cilia in Brain Organotypic and Cell Culture Models
The wall of the ventricular system within the neuraxis is lined almost entirely by E1 ependymal cells, each of which projects multiple motile cilia...
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High-capacity sample multiplexing for single cell chromatin accessibility profiling
Single-cell chromatin accessibility has emerged as a powerful means of understanding the epigenetic landscape of diverse tissues and cell types, but...
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Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures
The low number of neural progenitor cells (NPCs) present in the adult and aged primate brains represents a challenge for generating high-yield and...
