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Molecular evolution of transcription factors AF4/FMR2 family member (AFF) gene family and the role of lamprey AFF3 in cell proliferation
AF4/FMR2 family member (AFF) proteins are a group of transcriptional regulators that can regulate gene transcription and play an important role in...
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Role of the human solute carrier family 14 member 1 gene in hypoxia-induced renal cell carcinoma occurrence and its enlightenment to cancer nursing
BackgroundHypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. However, the potential...
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The prevalence of pharmacogenetic variants of vitamin K epoxide reductase complex subunit 1 gene (rs9923231), cytochrome P450 family 2 subfamily C member 9 gene (rs1799853) and cytochrome P450 family 3 subfamily-A member-5 gene (rs776746) among 13 ethnic groups of Pakistan
BackgroundPharmacogenomics (PGx) plays a central role in the selection of targeted therapies that underpins precision-medicine. We investigated the...
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Genome-wide analyses of member identification, expression pattern, and protein–protein interaction of EPF/EPFL gene family in Gossypium
BackgroundEpidermal patterning factor / -like ( EPF/EPFL ) gene family encodes a class of cysteine-rich secretory peptides, which are widelyfound in...
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CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity
cGAS/DncV-like nucleotidyltransferase (CD-NTase) family members are immune sensors that synthesize diverse nucleotide signals to initiate antiviral...
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Kinesin family member 11 promotes progression of hepatocellular carcinoma via the OCT4 pathway
Hepatocellular carcinoma (HCC) is the tumor with the second highest mortality rate worldwide. Recent research data show that KIF11, a member of the...
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APP family member dimeric complexes are formed predominantly in synaptic compartments
BackgroundThe amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Genomic-Wide Analysis Identifies the PI-PLC Gene Family and Expression of Its Member PsnPI-PLC6 Confers Cadmium Tolerance in Transgenic Tobacco Plants
AbstractThe phospholipase C are key enzymes in phospholipid signaling in plant growth, development, biotic, and abiotic stress responses. So far,...
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Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/β-catenin pathway
Kinesin family member 23 (KIF23) serves as a tumor-promoting gene with prognostic values in various tumors. However, the role of KIF23 in esophageal...
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OsVPE2, a Member of Vacuolar Processing Enzyme Family, Decreases Chilling Tolerance of Rice
Chilling is a major abiotic stress affecting rice growth, development and geographical distribution. Plant vacuolar processing enzymes (VPEs)...
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Genome-wide identification, molecular evolution and gene expression of P450 gene family in Cyrtotrachelus buqueti
BackgroundInsect Cytochrome P450 monooxygenase ( CYPs or P450 s) plays an important role in detoxifying insecticides, causing insect populations to...
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Genome-wide identification and stress response analysis of BcaCPK gene family in amphidiploid Brassica carinata
BackgroundCalcium-dependent protein kinases (CPKs) are crucial for recognizing and transmitting Ca 2+ signals in plant cells, playing a vital role in...
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Dynamic evolution of the mTHF gene family associated with primary metabolism across life
BackgroundThe folate cycle of one-carbon (C1) metabolism, which plays a central role in the biosynthesis of nucleotides and amino acids, demonstrates...
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Approaches to increase the validity of gene family identification using manual homology search tools
Identifying homologs is an important process in the analysis of genetic patterns underlying traits and evolutionary relationships among species....
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Pyrofollis japonicus gen. nov. sp. nov., a novel member of the family Pyrodictiaceae isolated from the Iheya North hydrothermal field
A novel hyperthermophilic, heterotrophic archaeon, strain YC29 T , was isolated from a deep-sea hydrothermal vent in the Mid-Okinawa Trough, Japan....
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Description of Flavimaribacter sediminis gen. nov., sp. nov., a New Member of the Family Rhizobiaceae Isolated from Marine Sediment
A novel Gram-staining-negative, aerobic and rod-shaped bacterium, designated WL0058 T , was isolated from coastal sediment sample collected in Nantong...
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Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity
Two mammalian homologs of systemic RNA interference defective protein 1 (SID-1) (SIDT1/2) are suggested to function as double-stranded RNA (dsRNA)...
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Genome-wide identification of bZIP gene family and expression analysis of BhbZIP58 under heat stress in wax gourd
BackgroundThe basic leucine zipper (bZIP) transcription factor family is one of the most abundant and evolutionarily conserved gene families in...
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Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation
BackgroundThe development of alcohol-associated liver disease (ALD) is influenced by the amount and duration of alcohol consumption. The resulting...
