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System Biology Approach in Investigating Epithelial-Mesenchymal Transition (EMT)
Epithelial-mesenchymal transition (EMT) is a trans-differentiating and reversible process that leads to dramatic cell phenotypic changes, enabling...
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Epithelial–mesenchymal transition in tissue repair and degeneration
Epithelial–mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic development and cancer; during EMT, epithelial cells...
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Tight Junctions, Epithelial-Mesenchymal Transition, and Cancer Metastasis
Epithelial-mesenchymal transition (EMT) induces dynamic changes in the cellular organization leading to functional changes in cell migration,...
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NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB...
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The implication of ciliary signaling pathways for epithelial–mesenchymal transition
Epithelial-to-mesenchymal transition (EMT), which plays an essential role in development, tissue repair and fibrosis, and cancer progression, is a...
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Epithelial-mesenchymal Transition (EMT) and the Effect of Atorvastatin on it in ARPE-19 cells
Proliferative vitreoretinopathy (PVR) develops after an unsuccessful or complicated recovery from rhegmatogenous retinal detachment (RRD) surgery....
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Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing
The epicardium is the important outermost mesothelial/epithelial layer of the heart that serves as a signaling center for cardiac development and...
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CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells
Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the...
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Adipokines and epithelial-mesenchymal transition (EMT) in cancer
Obesity is a significant risk factor for cancer development. Within the tumor microenvironment, adipocytes interact with cancer cells, immune cells,...
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The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
Of all pancreatic cancer (PC) cases, approximately 90% are pancreatic ductal adenocarcinoma (PDAC), which progress rapidly due to its high degree of...
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Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis
Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of...
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KIF4A promotes epithelial–mesenchymal transition by activating the TGF-β/SMAD signaling pathway in glioma cells
Gliomas are the most prevalent type of primary brain tumor, with poor prognosis reported in patients with high-grade glioma. Kinesin family member...
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MLL3 loss drives metastasis by promoting a hybrid epithelial–mesenchymal transition state
Phenotypic plasticity associated with the hybrid epithelial–mesenchymal transition (EMT) is crucial to metastatic seeding and outgrowth. However, the...
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Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible phenotype switch via the loss of...
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Comprehensive molecular interaction map of TGFβ induced epithelial to mesenchymal transition in breast cancer
Breast cancer is one of the prevailing cancers globally, with a high mortality rate. Metastatic breast cancer (MBC) is an advanced stage of cancer,...
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Effect of atractylenolide III on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium
BackgroundThe intestinal epithelium performs essential physiological functions, such as nutrient absorption, and acts as a barrier to prevent the...
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Epithelial-Mesenchymal Transition: Molecular Mechanisms of Retinal Pigment Epithelial Cell Activation
AbstractActivated cells of human retinal pigment epithelium (RPE) are the main effector cells in the process of fibrosis, the main pathological...
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MiR-326-mediated overexpression of NFIB offsets TGF-β induced epithelial to mesenchymal transition and reverses lung fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a progressively fatal and incurable disease characterized by the loss of alveolar structures, increased...
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TGFβ2 mediates oxidative stress–induced epithelial-to-mesenchymal transition of bladder smooth muscle
Bladder outlet obstruction (BOO) is the primary clinical manifestation of benign prostatic hyperplasia, the most common urinary system disease in...
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Regulating epithelial-mesenchymal plasticity from 3D genome organization
Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in...
