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1. Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo

   Background

   Stem cell therapy is a promising therapeutic strategy. In a previous study, we evaluated tumorigenicity by the stereotactic transplantation...

   Lili Guo, Dan Zou, ... Ruxiang Xu in Cellular and Molecular Life Sciences

   Article Open access 14 April 2024
   

2. Retinoic Acid-Mediated Differentiation of Mouse Embryonic Stem Cells to Neuronal Cells

   The capability of pluripotent embryonic stem cells (ESCs) to proliferate and differentiate into specific lineages makes them an important avenue of...

   Sangeeta Dutta, Debosree Pal, M. R. S. Rao in Stem Cells and Lineage Commitment

   Protocol 2023
   

3. In Vitro Differentiation of Murine Embryonic Stem Cells (ESCs) into Primordial Germ Cell-like Cells (PGCLCs)

   The ability to generate primordial germ cell-like cells (PGCLCs) from murine embryonic stem cells (ESCs) has enabled in vitro investigation of the...

   Han-Pin Pui, Qiaolin Deng in Epiblast Stem Cells

   Protocol 2022
   

4. Development and application of haploid embryonic stem cells

   Haploid cells are a kind of cells with only one set of chromosomes. Compared with traditional diploid cells, haploid cells have unique advantages in...

   Hai-Song Wang, **n-Rui Ma, Yi-Hong Guo in Stem Cell Research & Therapy

   Article Open access 23 April 2024
   

5. miR-322 promotes the differentiation of embryonic stem cells into cardiomyocytes

   Previous studies have shown that miR-322 regulates the functions of various stem cells. However, the role and mechanism of embryonic stem cell (ESCs)...

   Kai Liu, ** Peng, Liang Luo in Functional & Integrative Genomics

   Article 18 March 2023
   

6. Rat Embryonic Stem Cell Transgenesis

   The availability of reliable germline competent rat embryonic stem cell (ESC) lines that can be genetically manipulated provides an important tool...

   Elizabeth C. Bryda, Hongsheng Men, Barbara J. Stone in Transgenesis

   Protocol 2023
   

7. LINE-1 Retrotransposition Assays in Embryonic Stem Cells

   The ongoing mobilization of active non-long terminal repeat (LTR) retrotransposons continues to impact the genomes of most mammals, including humans...

   Marta Garcia-Cañadas, Francisco J. Sanchez-Luque, ... Jose L. Garcia Perez in Transposable Elements

   Protocol 2023
   

8. Pig blastocyst-like structure models from embryonic stem cells

   Pluripotent stem cells have the potential to generate embryo models that can recapitulate developmental processes in vitro. Large animals such as...

   **zhu **ang, Hanning Wang, ... Duanqing Pei in Cell Discovery

   Article Open access 02 July 2024
   

9. Gene Targeting in Rat Embryonic Stem Cells

   Rat germline-competent embryonic stem (ES) cell lines have been available since 2008, and rat models with targeted mutations have been successfully...

   Hongsheng Men, Daniel J. Davis, Elizabeth C. Bryda in Transgenesis

   Protocol 2023
   

10. Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation

    Background

    Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation,...

    Kevin C. L. Cheng, Jennifer M. Frost, ... Miguel R. Branco in Epigenetics & Chromatin

    Article Open access 16 October 2023
    

11. Generation of Salivary Gland Organoids from Mouse Embryonic Stem Cells

    Salivary glands are exocrine glands composed of several cell types, including the ductal, acinar, and basal/myoepithelial cells. They play important...

    Junichi Tanaka, Kenji Mishima in Stem Cell Assays

    Protocol 2022
    

12. Metabolic and cell cycle shift induced by the deletion of Dnm1l attenuates the dissolution of pluripotency in mouse embryonic stem cells

    Mitochondria are versatile organelles that continuously change their morphology via fission and fusion. However, the detailed functions of...

    Bong Jong Seo, Seung Bin Na, ... Jeong Tae Do in Cellular and Molecular Life Sciences

    Article 25 September 2023
    

13. Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells

    The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse embryonic stem cells (ESCs) but rapidly decreases following...

    Satsuki Miyazaki, Hiroyuki Yamano, ... Jun-ichi Miyazaki in Communications Biology

    Article Open access 24 July 2023
    

14. Characterization of a Distinct State in the Continuum of Pluripotency Facilitated by Inhibition of PKCζ in Mouse Embryonic Stem Cells

    Inhibition of PKC (PKCi) signaling maintains pluripotency of embryonic stem cells (ESCs) across different mammalian species. However, the position of...

    Ishita Baral, Mayur Balkrishna Shirude, ... Debasree Dutta in Stem Cell Reviews and Reports

    Article 13 February 2023
    

15. Derivation of Bovine Primed Embryonic Stem Cells from Somatic Cell Nuclear Transfer Embryos

    Derivation of bovine embryonic stem cells from somatic cell nuclear transfer embryos enables the derivation of genetically matched pluripotent stem...

    Delia A. Soto, Micaela Navarro, Pablo J. Ross in Somatic Cell Nuclear Transfer Technology

    Protocol 2023
    

16. DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation

    As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation...

    Mathieu Schulz, Aurélie Teissandier, ... Deborah Bourc’his in Nature Structural & Molecular Biology

    Article 04 January 2024
    

17. RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation

    Purpose of Review

    The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of...

    Wei Fan, **aoling Li in Current Stem Cell Reports

    Article Open access 09 May 2024
    

18. DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells

    Upon stimulation by extrinsic stimuli, stem cells initiate a programme that enables differentiation or self-renewal. Disruption of the stem state...

    Raghav Ramabadran, Jarey H. Wang, ... Margaret A. Goodell in Nature Cell Biology

    Article 06 April 2023
    

19. Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression

    The production of induced neuronal (iN) cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells by the forced expression of...

    Yingfei Liu, **zhao Wang, ... Marius Wernig in Nature Protocols

    Article 18 August 2023
    

20. Stem Cells and Therapies in Cardiac Regeneration

    Ischemic heart diseases (IHD) are a significant cause of death all over the world increasing the cardiovascular disease (CVD) burden. Blockade of...

    Harshavardhan Renikunta, Rituparna Chakrabarti, ... Praphulla Chandra Shukla in Regenerative Medicine

    Chapter 2023