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Mycobacterium tuberculosis virulence protein ESAT-6 influences M1/M2 polarization and macrophage apoptosis to regulate tuberculosis progression
BackgroundTuberculosis (TB) is an infectious disease caused by infection with Mycobacterium tuberculosis (Mtb), and it remains one of the major...
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Evaluating the Performance of PPE44, HSPX, ESAT-6 and CFP-10 Factors in Tuberculosis Subunit Vaccines
Mycobacterium tuberculosis ( M. tuberculosis ) is an intracellular pathogen causing long-term infection in humans that mainly attacks macrophages and...
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Differences in plasma proteomes for active tuberculosis, latent tuberculosis and non-tuberculosis mycobacterial lung disease patients with and without ESAT-6/CFP10 stimulation
BackgroundTuberculosis (TB) is one of the world’s most problematic infectious diseases. The pathogen Mycobacterium tuberculosis ( Mtb ) is contained...
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Diagnostic Potential of the Serological Response to Synthetic Peptides from Mycobacterium tuberculosis Antigens for Discrimination Between Active and Latent Tuberculosis Infections
Diagnosis and treatment of active tuberculosis (ATB) as well as latent tuberculosis infection (LTBI) are required for effective tuberculosis (TB)...
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Synthesis of plant-based, self-adjuvanted, dual antigen specific to Mycobacterium tuberculosis as a novel tuberculosis subunit vaccine that elicits immunogenicity in rabbit
ObjectivesThe only approved vaccine, Bacillus Calmette Guérin (BCG) used in global tuberculosis (TB) immunization programmes has been very effective...
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A microfluidic-based analysis of 3D macrophage migration after stimulation by Mycobacterium, Salmonella and Escherichia
Macrophages play an essential role in the process of recognition and containment of microbial infections. These immune cells are recruited to...
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The Future of Serology-Based Diagnosis for Tuberculosis in India
Tuberculosis (TB) is a major public health problem in India, with an estimated 2.42 million cases in 2022. Traditional diagnostic methods for...
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Plant Molecular Farming for Vaccine Development
Vaccines are effective tools for the prophylaxis of infectious diseases. Various diseases have been eradicated using vaccines, and the importance of...
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Latent Tuberculosis: Challenges in Diagnosis and Treatment, Perspectives, and the Crucial Role of Biomarkers
Tuberculosis (TB) is the major cause of morbidity and mortality globally, which is caused by a single infectious agent Mycobacterium tuberculosis ....
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Sensor and Nanotechnology-Based Diagnostics in the Field of Mycobacteriology
For many decades, tuberculosis (TB) has remained a serious global health issue since it is causing incalculable mortality by a single infectious...
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Production and Evaluation of Ag85B:HspX:hFcγ1 Immunogenicity as an Fc Fusion Recombinant Multi-Stage Vaccine Candidate Against Mycobacterium tuberculosis
An urgent need is to introduce an effective vaccine against Mycobacterium tuberculosis ( M.tb ) infection. In the present study, a multi-stage M.tb ...
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Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Lipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis...
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The pan-genome of Mycobacterium avium subsp. paratuberculosis (Map) confirms ancestral lineage and reveals gene rearrangements within Map Type S
BackgroundTo date genomic studies on Map have concentrated on Type C strains with only a few Type S strains included for comparison. In this study...
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Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of death in people living with human immunodeficiency virus (HIV)....
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The physiological effect of rimI/rimJ silencing by CRISPR interference in Mycobacterium smegmatis mc2155
N-terminal acetylation of proteins is an important post-translational modification (PTM) found in eukaryotes and prokaryotes. In bacteria, N-terminal...
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Deletion of the β-Propeller Protein Gene Rv1057 Reduces ESAT-6 Secretion and Intracellular Growth of Mycobacterium tuberculosis
Rv1057 is the only β-propeller protein in Mycobacterium tuberculosis , but its biological function is still unclear. In this study, we generated a...
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Analysis of the components of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function
BackgroundMycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) is a peptide antigen released from the mycobacterial cytoplasm into the...
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Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis promotes caspase-9/caspase-3-mediated apoptosis in macrophages
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that triggers several survival mechanisms against the host immune system. Many studies...
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Mycobacterium tuberculosis exploits MPT64 to generate myeloid-derived suppressor cells to evade the immune system
Mycobacterium tuberculosis (Mtb) is a smart and successful pathogen since it can persist in the intimidating environment of the host by taming and...
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Mycobacterium tuberculosis and its clever approaches to escape the deadly macrophage
Mycobacterium tuberculosis (Mt.b ), a deadly disease causer, is a facultative parasite. This microorganism has developed several methods to defend...
