Abstract
Tuberculosis (TB) is a major public health problem in India, with an estimated 2.42 million cases in 2022. Traditional diagnostic methods for tuberculosis (TB) in India are limited in their accuracy and specificity. Sputum smear microscopy is the most widely used method, but it has a sensitivity of around 30–50%. Culture-based methods are more sensitive, but they are expensive, time-consuming, and require specialized laboratory facilities. As a result, there is a need for alternative diagnostic methods that are more accurate, specific, and cost-effective.
Serology-based diagnosis has been proposed as an alternative approach for TB diagnosis. Serological tests detect antibodies against Mycobacterium tuberculosis (M. tuberculosis) antigens in the blood of patients. They are simple, rapid, and can be performed in a standard laboratory setting. However, the performance of serological tests in the diagnosis of pulmonary TB has been poor, with low sensitivity and specificity. In addition, the interpretation of serological markers remains a challenge, and the heterogeneity of M. tuberculosis strains can complicate the diagnosis of TB. Also, the economic implications of serological testing for TB are also substantial. Therefore, the use of serological tests for TB diagnosis in India needs to be carefully evaluated in terms of cost-effectiveness.
Despite the limitations, serology-based diagnosis has the potential to improve TB diagnosis in India. Serological tests can provide rapid results, allowing for early detection and timely initiation of treatment. This is crucial in a country like India, where TB is a major public health concern. Serological tests can also help improve the overall diagnostic accuracy and enhance the detection of TB cases. However, more research is needed to improve the accuracy and specificity of serological tests and to evaluate their cost-effectiveness. Overall, serology-based diagnosis is a promising approach for TB diagnosis in India. However, more research is needed to make it a more reliable and cost-effective diagnostic tool.
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Malhotra, A.G., Gupta, A.K., Singh, A. (2023). The Future of Serology-Based Diagnosis for Tuberculosis in India. In: Singh, A., Sharma, D. (eds) Diagnosis of Mycobacterium. Springer, Singapore. https://doi.org/10.1007/978-981-99-5624-1_9
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