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Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death
The dual specificity protein phosphatases (Dusps) control dephosphorylation of mitogen-activated protein kinases (MAPKs) as well as other substrates....
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Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor β1(TGFβ1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells
BackgroundTransforming Growth Factor β (TGFβ) proteins are potent inducers of the epithelial-mesenchymal transition (EMT) in tumor cells. Although...
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Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database
BackgroundBreast cancer has remained the most common malignancy in women over the past two decades. As lifestyle and living environments have...
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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart
BackgroundDiabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly...
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Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing...
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Genomic selection pressure discovery using site-frequency spectrum and reduced local variability statistics in Pakistani Dera-Din-Panah goat
BackgroundPopulation geneticists have long sought to comprehend various selection traces accumulated in the goat genome due to natural or human...
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AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis
The RAS–BRAF signaling is a major pathway of cell proliferation and their mutations are frequently found in human cancers. Adenylate kinase 2 (AK2),...
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Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases
Cardiometabolic diseases are frequently polygenic in architecture, comprising a large number of risk alleles with small effects spread across the...
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DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling
Osteoporosis-related fractures, such as femoral neck and vertebral fractures, are common in aged people, resulting in increased disability rate and...
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Spatial tissue profiling by imaging-free molecular tomography
Several techniques are currently being developed for spatially resolved omics profiling, but each new method requires the setup of specific detection...
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NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis
Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting...
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Genome–wide association study for risk taking propensity indicates shared pathways with body mass index
Risk-taking propensity is a trait of significant public health relevance but few specific genetic factors are known. Here we perform a genome-wide...
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Genome-wide expression profiling in muscle and subcutaneous fat of lambs in response to the intake of concentrate supplemented with vitamin E
BackgroundThe objective of this study was to acquire a broader, more comprehensive picture of the transcriptional changes in the L. Thoracis muscle...
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Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs
BackgroundOne of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for...
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The Extended Family of Protein Tyrosine Phosphatases
In higher eukaryotes, the Tyr phosphorylation status of cellular proteins results from the coordinated action of Protein Tyrosine Kinases (PTKs) and...
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Protein Tyrosine Phosphatases in Mast Cell Signaling
For a time, mast cells were viewed as simple granulocytic effector cells that mediate allergic symptoms. More recent discoveries show that mast cells...
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DUSPs, to MAP kinases and beyond
Phosphatases are important regulators of intracellular signaling events, and their functions have been implicated in many biological processes....
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Effect of castration on carcass quality and differential gene expression of longissimus muscle between steer and bull
The effect of castration on carcass quality was investigated by ten Chinese Simmental calves. Five calves were castrated randomly at 2 months old and...
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Identification and expression patterns ofkif3az during the zebrafish embryonic development
I am reporting the identdficiation, expression patterns, and possible biological functions of zebrafish kif3a (kif3az) encoding 116 aminoacids. Kif3az...