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Expectations of duplicate gene retention under the gene duplicability hypothesis
BackgroundGene duplication is an important process in evolution. What causes some genes to be retained after duplication and others to be lost is a...
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Duplicate mutations of GhCYP450 lead to the production of ms5m6 male sterile line in cotton
Key messageThe duplicated male sterile genes ms 5 m 6 in cotton were map-based cloned and validated by the virus-induced gene silencing assays....
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Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
BackgroundThe nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila . Fast gene evolution and gene...
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Conversion between duplicated genes generated by polyploidization contributes to the divergence of poplar and willow
BackgroundGene conversion has an important effect on duplicate genes produced by polyploidization. Poplar ( Populus trichocarpa ) and willow ( Salix...
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Duplication of genes and genomes in yeasts
The molecular evolution of the group of yeasts closely related to Saccharomyces cerevisiae has been profoundly affected by an ancient polyploidy...
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QTL and Candidate Genes for Flax Disease Resistance
Rust, pasmo (PAS), powdery mildew (PM), and Fusarium wilt (FW) are four major diseases of flax, causing yield losses as well as seed and fiber...
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Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum
BackgroundDespite having been extensively studied, it remains largely unclear why humans bear a particularly high risk of cancer. The antagonistic...
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Endogenous Tagging of Ciliary Genes in Human RPE1 Cells for Live-Cell Imaging
CRISPR-mediated endogenous tagging of genes provides unique possibilities to explore the function and dynamic subcellular localization of proteins in...
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The evolution of NLRC3 subfamily genes in Sebastidae teleost fishes
BackgroundWith more than 36,000 valid fish species, teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic...
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Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences
BackgroundDuring evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than...
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Extent of Virulence and Antibiotic Resistance Genes in Helicobacter pylori and Campylobacteria
Helicobacter pylori , a member of the clade campylobacteria, is the leading cause of chronic gastritis and gastric cancer. Virulence and antibiotic...
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Co-localization of clusters of TCR-regulated genes with TAD rearrangements
BackgroundGene expression has long been known to be influenced by the relative proximity of DNA regulatory elements. Topologically associating...
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Identification and analysis of key hypoxia- and immune-related genes in hypertrophic cardiomyopathy
BackgroundHypertrophic cardiomyopathy (HCM), an autosomal dominant genetic disease, is the main cause of sudden death in adolescents and athletes...
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Mitochondrial genomes revisited: why do different lineages retain different genes?
The mitochondria contain their own genome derived from an alphaproteobacterial endosymbiont. From thousands of protein-coding genes originally...
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Identification and expression analysis of Sox family genes in echinoderms
The Sox gene family, a collection of transcription factors widely distributed throughout the animal kingdom, plays a crucial role in numerous...
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Superior haplotypes of key drought-responsive genes reveal opportunities for the development of climate-resilient rice varieties
Haplotype-based breeding is an emerging and innovative concept that enables the development of designer crop varieties by exploiting and exploring...
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Identification of six genes associated with COVID-19-related circadian rhythm dysfunction by integrated bioinformatic analysis
Patients with coronavirus disease 2019 (COVID-19) might cause long-term burden of insomnia, while the common pathogenic mechanisms are not...
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RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
Proneural genes play a crucial role in neuronal differentiation. However, our understanding of the regulatory mechanisms governing proneural genes...
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Downregulation of Essential Genes in the Fungal Pathogen Candida auris
The recent global emergence of the fungal pathogen Candida auris has caused significant concern given that this pathogen often exhibits resistance to...