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Synthesis and Optical Properties of the Conformationally Locked Diarylmethene Derivative of the GFP Chromophore
Abstract—We report a novel derivative of the conformationally locked derivative of the green fluorescent protein chromophore, ( Z )-5-((2-(difluoroboryl)-4-(dimethylamino)phenyl)(4-(dimethylamino)phenyl)methylene)-2-propyl-3,5-dihydro-4...
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Synthesis, Characterization, and In Vivo Evaluation of Escitalopram Analogues for Depression
AbstractEscitalopram, ( S )-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, is a highly selective and potent...
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Cytotoxic and Apoptotic Effects of Tin(IV) Complexes Containing a Schiff Base Derived from Cephalexin on a Breast Cancer Cell Line
Metal complexes containing heterocycles have wide pharmaceutical and medicinal applications. The biological activities of the complexes are...
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Preparation of near-infrared AIEgen-active fluorescent probes for map** amyloid-β plaques in brain tissues and living mice
Fibrillar aggregates of the amyloid-β protein (Aβ) are the main component of the senile plaques found in brains of patients with Alzheimer’s disease...
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Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease
BackgroundCoronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on...
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Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo
The zebrafish is a useful model to identify genes functioning in hematopoiesis, owing to high conservation of hematopoiesis. Flow cytometry is widely...
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Targeting Staphylococcus aureus and its biofilms with novel antibacterial compounds produced by Lactiplantibacillus plantarum SJ33
The emergence of microbial resistance to conventional antibiotics, partially attributed to biofilm formation, has urged for new antimicrobial...
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Hypothesis on the Endocrine System of the Brain: Evidence for the Regulated Delivery of Neurohormones from the Brain to the Cerebrospinal Fluid and Vice Versa in Neonatal and Prepubertal Periods of Ontogenesis
AbstractThe extensive information accumulated over the past few decades on the important role of cerebrospinal fluid in many physiological processes...
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Synthesis, Characterization of Formazan Derivatives from Isoniazid and Study Their Antioxidant Activity and Molecular Docking
AbstractObjective: Synthesis, Characterization of formazan derivatives and studies the antioxidant activity of prepared compounds and molecular...
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Mirabilis: Medicinal Uses and Conservation
Among the estimated 35,000 to 70,000 medicinally important plant species, the genus Mirabilis is a significant perennial herb resides to...
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Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides
Cell-penetrating peptides (CPPs) are promising delivery vehicles. These short peptides can transport wide range of cargos into cells, although their...
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Extraction and Quantification of Guanitoxin from Aquatic Samples by HPLC-MS
Guanitoxin is a neurotoxin formed by certain cyanobacterial strains such as Dolichospermum and Sphaerospermopsis. Due to its permanent suppression of...
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DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson’s disease
The loss of dopaminergic neurons in the substantia nigra is a hallmark of pathology in Parkinson’s disease (PD). Dimethylarginine...
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Antiviral activity of Turbinaria ornata against white spot syndrome virus in freshwater crab (Paratelphusa hydrodromous)
White spot disease in penaeid shrimp is caused by white spot syndrome virus and causing serious threat to shrimp farming industry. The present study...
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Pre-clinical evaluation of 99mTc-labeled chalcone derivative for amyloid-β imaging post-head trauma
Aβ 42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most...
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Visible Light Bioluminescence Imaging Platform for Animal Cell Imaging
The present protocol introduces a visible light bioluminescence imaging (BLI) platform together with 12 novel coelenterazine (CTZ) analogues and...
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Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell
This study demonstrates the potential of sono-photodynamic therapy as an effective approach for enhancing singlet oxygen generation using the...
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Synthesis, Antibacterial, and Antifungal Evaluation of New Class of Pyrimido[4,5-d]pyrimidine, Pyrazolo[3,4-d]pyrimidine, and Pyrimido[4,5-b]quinoline Derived from α,α-Ketene Dithioacetals as fused Five and Six-membered Heterocycle Derivatives
AbstractA novel heterocyclic compounds containing pyrimido[4,5- d ]pyrimidine ( IIIa–IIIb ) and ( IVa–IVb ), pyrazolo[3,4- d ]pyrimidine ( Va'–Ve' ) and ( VIa'–VIe'...
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Synthesis and Urease Inhibition Activities of Some New Schiff Bases Benzimidazoles Containing Thiophene Ring
AbstractObjective: Schiff bases are significant pharmacophores and show varied biological applications such as antiurease, antidiabetic,...
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Developments of pyridodipyrimidine heterocycles and their biological activities
The entitled review aimed to assemble and highlight the synthetic approaches and biological aspects of heterocycles with pyridodipyrimidine motifs....
