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Validation of Fourier Transform Infrared Microspectroscopy for the Evaluation of Enzymatic Cross-Linking of Bone Collagen
Enzymatic cross-linking of the bone collagen is important to resist to crack growth and to increased flexural strength. In the present study, we...
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The Contribution of Perilacunar Composition and Mechanical Properties to Whole-Bone Mechanical Outcomes in Streptozotocin-Induced Diabetes
Osteocytes are the most abundant cell type in bone and remodel their local perilacunar matrix in response to a variety of stimuli and diseases. How...
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Bone metabolism during strict head-down tilt bed rest and exposure to elevated levels of ambient CO2
Astronauts on the International Space Station are exposed to levels of atmospheric carbon dioxide (CO 2 ) above typical terrestrial levels. We explored...
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Osteoporosis Caused by Systemic Mastocytosis: Prevalence in a Cohort of 8392 Patients with Osteoporosis
Indolent systemic mastocytosis (ISM) is a group of heterogenous diseases characterized by abnormal accumulation of mast cells in at least one organ....
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Basic Bone Biology
Bone is a self-renewing, self-healing, composite material. It is organized as a hierarchical/multi-scale structure starting at the molecular level of...
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Bone Turnover Markers and Wnt Signaling Modulators in Early Complex Regional Pain Syndrome. A Pre-specified Observational Study
To explore serum levels of some bone turnover markers and the involvement of the Wnt signaling in CRPS-1. Query ID="Q1" Text="Please check and...
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Practical Considerations for the Clinical Application of Bone Turnover Markers in Osteoporosis
Bone turnover markers (BTMs) are released during the bone remodelling cycle and are measurable in blood or urine, reflecting bone remodelling rate....
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Assessment of the Phytochemical Constituents and Metabolites in Medicinal Plants and Herbal Remedies Used in the Treatment and Management of Reproductive Diseases: Polycystic Ovary Syndrome
The present study explores the phytochemical constituents and metabolites found in medicinal plants and herbal remedies traditionally used for...
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Evaluating the Role of Probiotics, Prebiotics, and Synbiotics Supplementation in Age-related Musculoskeletal Disorders in Older Adults: A Systematic Review
The aim of this systematic review is to evaluate musculoskeletal changes in response to prebiotics, probiotics, or synbiotics supplementation in...
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Effects of Infantile Hypophosphatasia on Human Dental Tissue
Hypophosphatasia (HPP) is an inherited, systemic disorder, caused by loss-of-function variants of the ALPL gene encoding the enzyme tissue...
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Assessment of Collagen in Translational Models of Lung Research
The extracellular matrix (ECM) plays an important role in lung health and disease. Collagen is the main component of the lung ECM, widely used for...
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Whole-Exome Sequencing Identifies Novel Compound Heterozygous ZNF469 Mutations in Two Siblings with Mild Brittle Cornea Syndrome
Connective tissue diseases, including osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS), exhibit a high degree of clinical and genetic...
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OPN, BSP, and Bone Quality—Structural, Biochemical, and Biomechanical Assessment in OPN−/−, BSP−/−, and DKO Mice
Osteopontin (OPN) and Bone Sialoprotein (BSP), abundantly expressed by osteoblasts and osteoclasts, appear to have important, partly overlap**...
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β-Cryptoxanthin from Satsuma Mandarin and Its Multiple Functions
Satsuma mandarin (Citrus unshiu Marc.), a unique Japanese citrus species, is one of the foods which have most abundant β-cryptoxanthin all over the...
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Hepatitis C-Associated Osteosclerosis: Improvement After Treatment with Sofosbuvir, Daclatasvir, and Ibandronate: Case Report and Literature Review
Hepatitis C-associated osteosclerosis (HCAO) remains a rare condition despite the growing prevalence of hepatitis C virus (HCV) infection worldwide....
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Radial HR-pQCT and Finite Element Analysis in HPP Patients are Superior in Identifying Susceptibility to Fracture-Associated Skeletal Affections Compared to DXA and Laboratory Tests
Hypophosphatasia (HPP) is an inborn disease that causes a rare form of osteomalacia, a mineralization disorder affecting mineralized tissues....
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Clinical and Radiological Characterization of Patients with Immobilizing and Progressive Stress Fractures in Methotrexate Osteopathy
Methotrexate (MTX) is one of the most commonly prescribed drugs for autoimmune rheumatic diseases. As there is no consensus on its negative effects...
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Medical Management for Fracture Prevention in Children with Osteogenesis Imperfecta
There are no licensed treatments for children with osteogenesis imperfecta. Children currently receive off-label treatment with bisphosphonates,...
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An update on magnesium and bone health
In 2009 EFSA Panel concludes that a cause and effect relationship has been established between the dietary intake of magnesium (Mg) and maintenance...
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Biochemical, structural and physical changes in aging human skin, and their relationship
Skin is the largest organ of the human body, having the purpose of regulating temperature, protecting us from microbes or mechanical shocks, and...
