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Polymeric nanoparticles for DNA vaccine-based cancer immunotherapy: a review
Cancer is one of the leading causes of death and mortality in the world. There is an essential need to develop new drugs or therapeutic approaches to...
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Synergistic Effect of Maternal Micronutrient Supplementation on ORFV DNA Vaccine Immune Response in a Pregnant Model
Contagious ecthyma is a contagious zoonotic disease caused by the Orf virus that can infect farm animals and humans, but no vaccine is available for...
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Transformed Salmonella typhimurium SL7207/pcDNA-CCOL2A1 as an orally administered DNA vaccine
The use of attenuated bacteria for oral delivery of DNA vaccines is a recent innovation. We designed and constructed the naked plasmid DNA vaccine...
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Staphylococcal enterotoxin B as DNA vaccine against breast cancer in a murine model
Recently, many efforts have been made to treat cancer using recombinant bacterial toxins and this strategy has been used in clinical trials of...
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Plant Molecular Farming for Vaccine Development
Vaccines are effective tools for the prophylaxis of infectious diseases. Various diseases have been eradicated using vaccines, and the importance of...
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Immunogenic and protective effects of an oral polylactic-co-glycolic acid nano encapsulated DNA vaccine encoding aopB gene of Aeromonas hydrophila in common carp
In this study, a DNA vaccine was designed based on the aopB gene of type III secretory system of Aeromonas hydrophila using the eukaryotic pCDNA3.1...
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Exosome-Based COVID-19 Vaccine
Extracellular vesicles (EVs) enable cell-to-cell communication and, by delivering antigens, can stimulate the immune response strongly. Approved in...
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A multipathogen DNA vaccine elicits protective immune responses against two class A bioterrorism agents, anthrax and botulism
AbstractThe potential use of biological agents has become a major public health concern worldwide. According to the CDC classification, Bacillus...
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Recent progress and major gaps in the vaccine development for African swine fever
The swine industry across the globe is recently facing a devastating situation imparted by a highly contagious and deadly viral disease, African...
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Systems Biology: A New Era for Vaccine Development; from Deductive Toward Inductive
Routine vaccination has always been a center of controversy due to its lack of acceptability among the masses. Adverse event (AE) study relating to...
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Innovative Vaccine Strategy: Self-Adjuvanting Conjugate Vaccines
Self-adjuvanting vaccines, covalent conjugates between antigens and adjuvants, are chemically well-defined compared with conventional vaccines...
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Vaccine approaches and treatment aspects against Crimean Congo hemorrhagic fever
Crimean-Congo hemorrhagic fever [CCHF] is a severe infectious viral disease caused by a tick borne virus which can lead to fatal hemorrhagic disease...
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DNA vaccine dual-expressing viral hemorrhagic septicemia virus glycoprotein and C-C motif chemokine ligand 19 induces the expression of immune-related genes in zebrafish (Danio rerio)
Glycoprotein (G protein)-based DNA vaccines are effective in protecting aquaculture fish from rhabdoviruses but the degree of immune response they...
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Nucleic acid-based vaccine platforms against the coronavirus disease 19 (COVID-19)
The coronavirus disease 2019 (COVID-19) pandemic has infected 673,010,496 patients and caused the death of 6,854,959 cases globally until today....
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Fish oral vaccine and mucosal immunity
Fish can be vaccinated by injection, intramuscularly (IM) or intraperitoneally (IP), and orally. Using oral immunization provides the most attractive...
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Chitosan-LeoA-DNA Nanoparticles Promoted the Efficacy of Novel LeoA-DNA Vaccination on Mice Against Helicobacter pylori
More than half of the world’s population is infected with Helicobacter pylori ( H. pylori ), which may lead to chronic gastritis, peptic ulcers, and...
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Development, Strategies, and Challenges for Tularemia Vaccine
Francisella tularensis is a facultative intracellular bacterial pathogen that affects both humans and animals. It was developed into a biological...
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Bacteriophage Virus-Like Particles: Platforms for Vaccine Design
Virus-like particles (VLPs) derived from bacteriophages have many applications in biomedical sciences, especially in the development of candidate...
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Influence of Microbiota on Vaccine Effectiveness: “Is the Microbiota the Key to Vaccine-induced Responses?”
Vaccines are one of the most powerful tools for preventing infectious diseases. To effectively fight pathogens, vaccines should induce potent and...
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mRNA Vaccine Platform: mRNA Production and Delivery
Abstract—Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which...
