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ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage
DNA repair is essential for successful propagation of genetic material and fidelity of transcription. Nucleotide excision repair (NER) is one of the...
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p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY
The tumour suppressor p53 is a nuclear transcription factor with key roles during DNA damage to enable a variety of cellular responses including cell...
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DNA damage signalling histone H2AX is required for tumour growth
Cancer most frequently develops in self-renewal tissues that are the target of genetic alterations due to mutagens or intrinsic DNA replication...
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The mechanistic role of cardiac glycosides in DNA damage response and repair signaling
Cardiac glycosides (CGs) are a class of bioactive organic compounds well-known for their application in treating heart disease despite a narrow...
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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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Mechanistic insights into DNA damage recognition and checkpoint control in plants
The plant DNA damage response (DDR) pathway safeguards genomic integrity by rapid recognition and repair of DNA lesions that, if unrepaired, may...
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ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription
The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial...
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Ataxia Telengectesia Protein Influences Bleomycin-Induced DNA Damage in Human Fibroblast Cells
Human cancer is caused mainly by exposure to genotoxic chemicals; therefore, cellular defence mechanisms against genotoxic stress are crucial....
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The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and...
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Post-Integrational DNA Repair of HIV-1 Is Associated with Activation of the DNA-PK and ATM Cellular Protein Kinases and Phosphorylation of Their Targets
AbstractIntegration of the DNA copy of HIV-1 genome into the cellular genome results in series of damages, repair of which is critical for successful...
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Molecular genetics of genotoxic stress signalling in plants
Cells are under constant threat by endogenous and exogenous factors affecting DNA integrity. In response, complex signalling networks are activated...
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Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation
Ionising radiation (IR) is widely used in cancer treatment, including for head and neck squamous cell carcinoma (HNSCC), where it induces significant...
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Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
All organisms possess molecular mechanisms that govern DNA repair and associated DNA damage response (DDR) processes. Owing to their relevance to...
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Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes
Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around...
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Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis
Cryptochromes (CRYs) act as blue-light photoreceptors that regulate development and circadian rhythms in plants and animals and as navigating...
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Filamentous nuclear actin regulation of PML NBs during the DNA damage response is deregulated by prelamin A
Nuclear actin participates in a continuously expanding list of core processes within eukaryotic nuclei, including the maintenance of genomic...
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The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer
AXL is a receptor tyrosine kinase that is often overexpressed in cancers. It contributes to pathophysiology in cancer progression and therapeutic...
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Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage
DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall...
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SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus responsible for the coronavirus disease 2019 (COVID-19) pandemic....
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Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice
BackgroundNeuropsychiatric disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), are common, multi-factorial and...
