Search
Search Results
-
Preventing/Reversing Adverse Effects of Endocrine Disruption on Mouse Testes by Normalizing Tissue Resident VSELs
AbstractReproductive health of men is declining in today’s world due to increased developmental exposure to endocrine-disrupting chemicals (EDCs). We...
-
Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature
The placenta is a unique organ for ensuring normal embryonic growth in the uterine. Here, we found that maternal RNA transcription in Dlk1-Dio3 ...
-
Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep
BackgroundIt is not uncommon for some individuals to retain certain primitive characteristics even after domestication or long-term intensive...
-
The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
BackgroundLong noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a...
-
Analysis of the Paternally-Imprinted DLK1–MEG3 and IGF2–H19 Tandem Gene Loci in NT2 Embryonal Carcinoma Cells Identifies DLK1 as a Potential Therapeutic Target
The paternally-imprinted genes insulin-like growth factor 2 ( IGF2 ), H19 , delta-like homologue 1 ( DLK1 ), and maternally-expressed gene 3 ( MEG3 ) are...
-
Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters
BackgroundThere is widespread interest in the three-dimensional chromatin conformation of the genome and its impact on gene expression. However,...
-
VarID2 quantifies gene expression noise dynamics and unveils functional heterogeneity of ageing hematopoietic stem cells
Variability of gene expression due to stochasticity of transcription or variation of extrinsic signals, termed biological noise, is a potential...
-
Testicular cancer in mice: interplay between stem cells and endocrine insults
BackgroundIncidence of type II germ cell tumors (T2GCT) has increased in young men possibly due to fetal/perinatal exposure to estrogenic compounds....
-
Epigenetic Regulation Disturbances on Gene Expression in Imprinting Diseases
Abstract—Epigenetic regulation is hereditary and non-hereditary changes in the expression of a particular gene without any corresponding structural...
-
Epigenetic Epidemiology of Obesity and Type 2 Diabetes
Type 2 diabetes (T2D) and obesity are multifactorial and polygenic metabolic diseases. Combinations of genetic and non-genetic risk factors such as...
-
miR-31-5p from placental and peripheral blood exosomes is a potential biomarker to diagnose preeclampsia
BackgroundPreeclampsia, a multisystem disorder of unknown etiology, is one of the leading causes of maternal and perinatal morbidity and mortality....
-
The evaluation of chitosan hydrogel based curcumin effect on DNMT1, DNMT3A, DNMT3B, MEG3, HOTAIR gene expression in glioblastoma cell line
BackgroundCancer is one of the most important causes of death worldwide. Some types of cancer, including glioblastoma, with a high potential for...
-
Genomic Imprinting and Random Monoallelic Expression
AbstractThe review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the...
-
Functional Implications of Intergenic GWAS SNPs in Immune-Related LncRNAs
Genome wide association studies (GWAS) have identified many loci contributing to genetic variation of complex traits. Immune mediated disorders are...
-
Long Non-coding RNAs, Lnc(ing) RNA Metabolism to Cancer Biology
The eukaryotic genome is represented by a vast proportion of non-coding regions, which in recent years have been attributed to have important...
-
-
MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells
Numerous studies have described the critical role played by microRNAs (miRNAs) in cancer progression and the potential of these small non-coding RNAs...
-
-
Reversing Uteropathies Including Cancer-Like Changes in Mice by Transplanting Mesenchymal Stromal Cells or XAR Treatment
Pluripotent, very small embryonic-like stem cells (VSELs) and tissue-committed ‘progenitors’ termed endometrial stem cells (EnSCs) are reported in...
-
The impact of DNA methylation on CTCF-mediated 3D genome organization
Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although the role of DNA methylation at gene promoters and repetitive...
