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Rotifer enrichment with DHA did not improve growth and survival rate of yellowtail clownfish (Amphiprion clarkii) larvae
Docosahexaenoic acid (DHA) enrichment of live food is a common practice to improve growth and survival of larvae. The current research aimed to test...
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Microbial production of docosahexaenoic acid (DHA): biosynthetic pathways, physical parameter optimization, and health benefits
Omega-3 fatty acids, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and α-linolenic acid (ALA), are essential polyunsaturated...
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DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease that usually occurs in the elderly, and docosahexaenoic acid (DHA) plays a therapeutic role in...
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Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Transmembrane protein 135 (TMEM135) is thought to participate in the cellular response to increased intracellular lipids yet no defined molecular...
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DHA attenuates CAR-T cell efficacy through aggravating exhaustion and inducing apoptosis
Chimeric antigen receptor-modified T cell (CAR-T) therapy is a newly developed adoptive treatment for cancer in recent years that has shown potential...
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Microalgae and Thraustochytrids are Sustainable Sources of Vegan EPA and DHA with Commercial Feasibility
Vegan diets preclude the availability of some of the essential fatty acids supplied by foods of animal origin. Significantly, eicosapentaenoic (EPA)...
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Development of Schizochytrium sp. strain HS01 with high-DHA and low-saturated fatty acids production by multi-pronged adaptive evolution
PurposeDocosahexaenoic acid (DHA) is an important omega-3 unsaturated fatty acid and has been widely applied in medicine, food additives, and feed...
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Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway
Presently, the supply of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) traditionally produced by marine fisheries will be insufficient...
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EPA and DHA promote cell proliferation and enhance activity of the Akt-TOR-S6K anabolic signaling pathway in primary muscle cells of turbot (Scophthalmus maximus L.)
Fish growth and health are predominantly governed by dietary nutrient supply. Although the beneficial effects of omega-3 polyunsaturated fatty acids...
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The benefits of flushing with Lemuru fish oil as a source of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on the performance of reproductive parameters in Garut ewes
This study aimed to evaluate and analyze the effects of a flushing diet containing Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) from...
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Capability of DHA biosynthesis in a marine teleost, Pacific saury Cololabis saira: functional characterization of two paralogous Fads2 desaturases and Elovl5 elongase
The Pacific saury Cololabis saira is an important fishery resource in the Far East, where it is appreciated for its high lipid content, which...
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DHA alleviates diet-induced skeletal muscle fiber remodeling via FTO/m6A/DDIT4/PGC1α signaling
BackgroundObesity leads to a decline in the exercise capacity of skeletal muscle, thereby reducing mobility and promoting obesity-associated health...
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Chitosan-based delivery of fish codon-optimised Caenorhabditis elegans FAT-1 and FAT-2 boosts EPA and DHA biosynthesis in Sparus aurata
Omega-3 long-chain polyunsaturated fatty acids ( n -3 LC-PUFA) are essential fatty acids required in healthy balanced diets for humans. To induce...
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Crosstalk of AsA/DHA and GSH/GSSG ratios’ role in growth-phase dependent antioxidative defense in euryhaline and freshwater microalgae: explored for the first time
The cooperative role of vital components of the antioxidative defense pathway in addition to redox couples was studied in a growth-phase dependent...
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PUFA synthase-independent DHA synthesis pathway in Parietichytrium sp. and its modification to produce EPA and n-3DPA
The demand for n-3 long-chain polyunsaturated fatty acids (n-3LC-PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), will...
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DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism
Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer with limited treatment options. Cisplatin (DDP) is used as a mainstay of...
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Fatty acid content and composition in tissues of Baikal grayling (Thymallus baicalensis), with a special focus on DHA synthesis
Long-chain polyunsaturated fatty acids of n-3 family (n-3 LC PUFAs) are physiologically essential compounds required for normal growth and...
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Dynamics of DHA and EPA supplementation: incorporation into equine plasma, synovial fluid, and surfactant glycerophosphocholines
IntroductionHorses with asthma or osteoarthritis frequently receive ω-3 fatty acid supplements. Docosahexaenoic (DHA; 22:6) and eicosapentaenoic...
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Lack of ∆5 Desaturase Activity Impairs EPA and DHA Synthesis in Fish Cells from Red Sea Bream and Japanese Flounder
Long-chain (≥ C 20 ) polyunsaturated fatty acids (LC-PUFA), such as eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA), are...
