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Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis
BackgroundNecrotic enteritis (NE) is a major enteric disease in poultry, yet effective mitigation strategies remain elusive. Deoxycholic acid (DCA)...
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An Eclectic Review on Dicarboxylic Acid Production Through Yeast Cell Factories and Its Industrial Prominence
Dicarboxylic acid (DCA) is a multifaceted chemical intermediate, recoursed to produce many industrially important products such as adhesives,...
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Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation
BackgroundHigh-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial...
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Dynamic Controlled Atmosphere Isolated or Associated with 1-MCP and Elevated Storage Temperature Affect the Overall Quality and Anaerobic Metabolism of ‘Royal Gala’ Apples
This study aimed to evaluate the effect of static controlled atmosphere (CA) and dynamic controlled atmospheres (DCA), isolated or associated with...
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The pro- and antineoplastic effects of deoxycholic acid in pancreatic adenocarcinoma cell models
BackgroundCommensal bacteria secrete metabolites that reach distant cancer cells through the circulation and influence cancer behavior. Deoxycholic...
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Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells
BackgroundSkeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids...
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Comparative analysis of proteomic adaptations in Enterococcus faecalis and Enterococcus faecium after long term bile acid exposure
BackgroundAll gastrointestinal pathogens, including Enterococcus faecalis and Enterococcus faecium , undergo adaptation processes during colonization...
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Bile Acids Alter the Autophagy and Mitogenesis in Skeletal Muscle Cells
Muscle atrophy decreases muscle mass with the subsequent loss of muscle function. Among the mechanisms that trigger sarcopeniaSarcopenia is...
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Differential Fibrotic Response of Muscle Fibroblasts, Myoblasts, and Myotubes to Cholic and Deoxycholic Acids
FibrosisFibrosis is a condition characterized by an increase in the components of the extracellular matrix (ECM). In skeletal muscle, the cells that...
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Temperature Variation During Dynamic Controlled Atmosphere Storage: Effects on the Quality of ‘Maxi Gala’ Apples
This study aimed to determine the temperature variation strategies in the first 30 days in dynamic controlled atmosphere storage based on respiratory...
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High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis
BackgroundThe aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein...
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The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile
The ability of bacterial pathogens to establish recurrent and persistent infections is frequently associated with their ability to form biofilms. Clost...
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Thermal proteome profiling unveils protein targets of deoxycholic acid in living neuronal cells
Bile acids, synthesized in the liver and modified by the gut microbiota, play vital roles in various physiological processes. The dysregulation of...
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Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice
Although emerging evidence shows that gut microbiota-mediated metabolic changes regulate intestinal pathogen invasions, little is known about whether...
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Distribution of plant species Iris sibirica and its vegetation affinity in Slovakia
Iris sibirica is a threatened plant species of the Central European flora, but its distribution and vegetation ecology in Slovakia have not been...
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The Effect of Aminoethoxyvinylglycine and Dynamic Controlled Atmosphere on the Storage of ‘Bartlett’ Pear
Storage trials of 4 and 8 months’ duration, using ‘Bartlett’ pear ( Pyrus communis ) fruit treated with and without aminoethoxyvinylglycine (AVG) and...
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Integrated Metabolomic and transcriptomic analyses reveal deoxycholic acid promotes transmissible gastroenteritis virus infection by inhibiting phosphorylation of NF-κB and STAT3
BackgroundAcute diarrhea, dehydration and death in piglets are all symptoms of transmissible gastroenteritis virus (TGEV), which results in...
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Cholecystectomy promotes colon carcinogenesis by activating the Wnt signaling pathway by increasing the deoxycholic acid level
PurposeCholecystectomy (XGB) is widely recognized as a risk factor for colon cancer (CC). Continuous exposure of the colonic epithelium to...
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Construction of Nonnatural Cysteine-Cross-Linked Phage Libraries
Phage display is a powerful technique for rapid construction and screening of peptide libraries with over 109 sequence diversity. The M13...
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Metaphase Cells Enrichment for Efficient Use in the Dicentric Chromosome Assay
The dicentric chromosome assay (DCA), is considered the ‘gold standard’ for radiation biodosimetry. Yet, DCA, as currently implemented, may be...
