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An Eclectic Review on Dicarboxylic Acid Production Through Yeast Cell Factories and Its Industrial Prominence

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Abstract

Dicarboxylic acid (DCA) is a multifaceted chemical intermediate, recoursed to produce many industrially important products such as adhesives, plasticizers, lubricants, polymers, etc. To bypass the shortcomings of the chemical methods of synthesis of DCA and to reduce fossil fuel footprints, bio-based synthesis is gaining attention. In pursuit of an eco-friendly sustainable alternative method of DCA production, microbial cell factories, and renewable organic resources are gaining popularity. Among the plethora of microbial communities, yeast is being favored industrially compared to bacterial fermentation due to its hyperosmotic and low pH tolerance and flexibility for gene manipulations. By application of rapidly evolving genetic manipulation techniques, the bio-based DCA production could be made more precise and economical. To bridge the gap between supply and demand of DCA, many strategies are employed to improve the fermentation. This review briefly outlines the advancements in DCA production using yeast cell factories with the exemplification of strain improvement strategies.

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Data Availability

There are no original data associated with this review manuscript and the relevant information provided has been cited appropriately.

Abbreviations

AA:

Adipic acid

CAGR:

Compound annual growth rate

DCA:

Dicarboxylic acid

FA:

Fumaric acid

GA:

Glutaric acid

GCA:

Glucaric acid

GRAS:

Generally recognized as safe

IA:

Itaconic acid

MA:

Malic acid

MCA:

Muconic acid

SA:

Succinic acid

TCA Cycle:

Tricarboxylic acid cycle

US DoE:

United States Department of Energy

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Funding

We are grateful to the Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur for the financial and infrastructure support to carry out the research work.

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Authors and Affiliations

  1. Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, SRM Nagar, Chengalpattu Dist., Kattankulathur, Tamil Nadu, 603203, India

    Ramalingam Kayalvizhi, Jayacumar Sanjana & Samuel Jacob

  2. School of Water, Energy and Environment, Cranfield University, Cranfield, MK43 0AL, UK

    Vinod Kumar

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  1. Ramalingam Kayalvizhi
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  2. Jayacumar Sanjana
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  3. Samuel Jacob
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  4. Vinod Kumar
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Contributions

Ramalingam Kayalvizhi and Jayacumar Sanjana equally share the first authorship and are involved in the literature collection, drafting of the manuscript, and illustration preparations. Vinod Kumar provided valuable inputs and critical suggestions for manuscript improvement. Samuel Jacob is responsible for the technical inputs and finalization of the manuscript.

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Correspondence to Samuel Jacob or Vinod Kumar.

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Kayalvizhi, R., Sanjana, J., Jacob, S. et al. An Eclectic Review on Dicarboxylic Acid Production Through Yeast Cell Factories and Its Industrial Prominence. Curr Microbiol 81, 147 (2024). https://doi.org/10.1007/s00284-024-03654-4

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