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Identification of a Novel Homozygous Missense Mutation in the CLDN16 Gene to Decipher the Ambiguous Clinical Presentation Associated with Autosomal Dominant Hypocalcaemia and Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis in an Indian Family
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHNNC) is a rare autosomal recessive renal tubulopathy disorder characterized by...
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Lactobacillus-derived metabolites enhance the antitumor activity of 5-FU and inhibit metastatic behavior in 5-FU-resistant colorectal cancer cells by regulating claudin-1 expression
Lactobacillus plantarum -derived metabolites (LDMs) increase drug sensitivity to 5-FU and antimetastatic effects in 5-FU-resistant colorectal cancer...
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The Impact of Paracoccidioides spp Infection on Central Nervous System Cell Junctional Complexes
Paracoccidioidomycosis (PCM), a systemic mycosis caused by the fungus Paracoccidioides spp . is the most prevalent fungal infection among...
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Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins
Epithelial barriers constitute a fundamental requirement in every organism, as they allow the separation of different environments and set boundaries...
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Dietary supplemental coated essential oils and organic acids mixture improves growth performance and gut health along with reduces Salmonella load of broiler chickens infected with Salmonella Enteritidis
BackgroundReducing Salmonella infection in broiler chickens by using effective and safe alternatives to antibiotics is vital to provide safer...
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Bromelain and ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cells
Enzyme therapy for celiac disease (CeD), which digests gliadin into non-immunogenic and non-toxic peptides, can be an appropriate treatment option...
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Tight Junction Proteins as Emerging Drug Targets: Expanding the Horizons from Inflammation to Cancer
Tight junctions (TJ), located at the most topical part of the cells, are multi-protein complexes that form a formidable barrier governing the...
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Tetrahydrocurcumin (THC) enhanced the clearance of Cryptococcus deneoformans during infection in vivo
Cryptococcal species often cause lung infections and are the main cause of fungal meningitis. Claudin-4 appears to be a major structural component...
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The synbiotic mixture of lactulose and Bacillus coagulans protects intestinal barrier dysfunction and apoptosis in weaned piglets challenged with lipopolysaccharide
BackgroundLactulose as an effective prebiotic protects intestinal mucosal injury. Bacillus coagulans is widely used in feed additives because of its...
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Claudin-6 increases SNAI1, NANOG and SOX2 gene expression in human gastric adenocarcinoma AGS cells
BackgroundGastric cancer is a heterogeneous disease associated to deregulated gastric epithelia tight junction barrier function and di novo ...
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Dietary supplementation with Piper sarmentosum extract on gut health of chickens infected with Eimeria tenella
To explore the potential alternative of anti-coccidials, we investigated the therapeutic efficacy of dietary Piper sarmentosum extract (PSE) on...
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Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion
Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available in vitro sandwich-cultured...
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Endothelial DR6 in blood-brain barrier malfunction in Alzheimer’s disease
The impairment of the blood-brain barrier (BBB) has been increasingly recognised as a critical element in the early pathogenesis of Alzheimer’s...
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Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling
Intestinal stem cells (ISCs) play a crucial role in the continuous self-renewal and recovery of the intestinal epithelium. In previous studies, we...
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Regulation of Tight Junction by Cadherin Adhesion and Its Implication in Inflammation and Cancer
Epithelial cells interact with their cellular microenvironment through the formation of different interactions between the plasma membrane-localized...
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Combined effects of cadmium and ochratoxin A on intestinal barrier dysfunction in human Caco-2 cells and pig small intestinal epithelial cells
Hazardous chemicals are commonly found in cereals and cereal-based products. However, most studies focus on the individual effects of these...
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Atopic dermatitis: molecular, cellular, and clinical aspects
Atopic dermatitis (AD) is a complicated, inflammatory skin disease, which numerous genetic and environmental factors play roles in its development....
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Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells
BackgroundMast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by...
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TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. The unregulated expression of Claudin-4 (CLDN4) plays an...
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Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
Maternal nutrition plays a critical role in energy metabolism of offspring. We aim to elucidate the effect of long-term intermittent fasting (IF)...
