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Targeted screening and identification of chlorhexidine as a pro-myogenic circadian clock activator
BackgroundThe circadian clock is an evolutionarily conserved mechanism that exerts pervasive temporal control in stem cell behavior. This...
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Study of Combined Effect of Bacteriophage vB3530 and Chlorhexidine on the Inactivation of Pseudomonas aeruginosa
BackgroundChlorhexidine (CHG) is a disinfectant commonly used in hospitals. However, it has been reported that the excessive use of CHG can cause...
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Impact of clonal lineages on susceptibility of Staphylococcus lugdunensis to chlorhexidine digluconate and chloride benzalkonium
BackgroundLittle is known about susceptibility of Staphylococcus lugdunensis to antiseptics. The objective of this study was to evaluate, at the...
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Cu-BTC metal–organic framework as a biocompatible nanoporous carrier for chlorhexidine antibacterial agent
Antibacterial materials are an essential part of modern life and many efforts have been made to find a new and effective type of them. In this study,...
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Polyhexamethylene guanidine hydrochloride as promising active ingredient for oral antiseptic products to eliminate microorganisms threatening the health of endangered wild cats: a comparative study with chlorhexidine digluconate
The aim of this study was to evaluate the antimicrobial efficacy of polyhexamethylene hydrochloride guanidine (PHMGH) compared to chlorhexidine...
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Combination of Cetylpyridinium Chloride and Chlorhexidine Acetate: A Promising Candidate for Rapid Killing of Gram-Positive/Gram-Negative Bacteria and Fungi
Combined use of the present antimicrobial drugs has been proved to be an alternative approach for antimicrobial agents’ development since the...
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Phenotypic and genotypic changes of Staphylococcus aureus in the presence of the inappropriate concentration of chlorhexidine gluconate
BackgroundChlorhexidine gluconate (CHG) is a disinfectant agent with different applications in health care. Improper use of CHG causes antimicrobial...
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The combined utilization of Chlorhexidine and Voriconazole or Natamycin to combat Fusarium infections
BackgroundFusarium species are the fungal pathogens most commonly responsible for the mycotic keratitis, which are resistant to the majority of...
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Sustained release varnish containing chlorhexidine for prevention of Streptococcus mutans biofilm formation on voice prosthesis surface: an in vitro study
ObjectivesIn this study, we aimed to develop a novel, sustained release varnish (SRV) for voice prostheses (VP) releasing chlorhexidine (CHX), for...
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Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
Acanthamoeba spp. emerged as a clinically important pathogen related to amoebic keratitis. It is among the main causes of corneal transplantation and...
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Oral biofilms exposure to chlorhexidine results in altered microbial composition and metabolic profile
Oral diseases (e.g., dental caries, periodontitis) are developed when the healthy oral microbiome is imbalanced allowing the increase of pathobiont...
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Synergistic efficacy of alkyltrimethylammonium bromide, chlorhexidine digluconate on diverse bacterial strains causing red-heat and purple-stain deteriorations of leather
This investigation assessed the synergistic effectiveness of alkyltrimethylammonium bromide (ATMB) and chlorhexidine digluconate (CDG) on selected...
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Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response
BackgroundEnvelope stress responses (ESRs) are critical for adaptive resistance of Gram-negative bacteria to envelope-targeting antimicrobial agents....
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Resistance profile and biofilm production of Enterococcus spp., Staphylococcus sp., and Streptococcus spp. from dairy farms in southern Brazil
Milk is a high nutritional value food that helps in human development and growth. However, it can also harbor microorganisms. Therefore, the...
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Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus
The past decade has seen an increase in the prevalence of sequence type (ST) 45 methicillin-resistant Staphylococcus aureus (MRSA), yet the...
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The influence of cationic antiseptics on the processes of light energy conversion in various photosynthetic pigment-protein complexes
The widespread use of disinfectants and antiseptics, and consequently their release into the environment, determines the relevance of studying their...
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Cheminformatics and machine learning approaches for repurposing anti-viral compounds against monkeypox virus thymidylate kinase
One of the emerging epidemic concerns is Monkeypox disease which is spreading globally. This disease is caused by the monkeypox virus (MPXV), with an...
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Inhibitory Effects and Mechanism of the Combined Use of α-Helical Peptides HPRP-A1/HPRP-A2 and Chlorhexidine Acetate Against Bacterial and Fungal Biofilms
Drug resistance is an increasing problem in the treatment of vaginitis bacterial vaginosis and vulvovaginal candidiasis caused by biofilm-forming...
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The antifungal and antibiofilm activity of Cymbopogon nardus essential oil and citronellal on clinical strains of Candida albicans
ObjectiveThis study investigated the antifungal and antibiofilm activity of Cymbopogon nardus essential oil (EO) and its major compound,...
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K+ homeostasis is important for survival of Acinetobacter baumannii ATCC 19606 in the nosocomial environment
Pathogenic bacteria have developed several mechanisms to thrive within the hostile environment of the human host, but it is often disregarded that...
