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The ENCODE Imputation Challenge: a critical assessment of methods for cross-cell type imputation of epigenomic profiles
A promising alternative to comprehensively performing genomics experiments is to, instead, perform a subset of experiments and use computational...
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The multimodality cell segmentation challenge: toward universal solutions
Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often...
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The Cell Tracking Challenge: 10 years of objective benchmarking
The Cell Tracking Challenge is an ongoing benchmarking initiative that has become a reference in cell segmentation and tracking algorithm...
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Titration-based normalization of antibody amount improves consistency of ChIP-seq experiments
Chromatin immunoprecipitation (ChIP) is an antibody-based approach that is frequently utilized in chromatin biology and epigenetics. The challenge in...
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Designing optimal experiments in metabolomics
BackgroundMetabolomics data is often complex due to the high number of metabolites, chemical diversity, and dependence on sample preparation. This...
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Low-dose dengue virus 3 human challenge model: a phase 1 open-label study
Dengue human infection models present an opportunity to explore the potential of a vaccine, anti-viral or immuno-compound for clinical benefit in a...
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The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery
Targeting aging is the future of twenty-first century preventative medicine. Small molecule interventions that promote healthy longevity are known,...
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Large-Scale Manipulative Experiments
This chapter provides an overview of manipulative experiments conducted at spatial extents of 15 ha or larger in forest, grassland, and aquatic...
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Gene expression response of Litopenaeus vannamei crustins in two specialized immune-related tissues upon Vibrio immersion challenge
The aim of this study was to characterize the transcriptional response of representative genes from the four crustin types (Type I, Lv Crustin Ia-6...
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Embracing Complexity: Yeast Evolution Experiments Featuring Standing Genetic Variation
The yeast Saccharomyces cerevisiae has a long and esteemed history as a model system for laboratory selection experiments. The majority of yeast...
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Effects of organic selenium-containing diets on Penaeus vannamei molecular response under induced heat stress challenge
Organic selenium is a major antioxidant that can protect against oxidative stresses by stimulating the antioxidant cascades. We have evaluated the...
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Genoty** of SNPs in bread wheat at reduced cost from pooled experiments and imputation
Key messagePooling and imputation are computational methods that can be combined for achieving cost-effective and accurate high-density genoty** of...
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Growth performance and immunomodulatory effect of Terminalia catappa L. diet on Litopenaeus vannamei against Vibrio parahaemolyticus challenge
Shrimp is a popular commodity due to its fast growth and high economic value. However, stress-related disease outbreaks caused by intensifying...
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Characterization of a membrane Fcγ receptor in largemouth bass (Micropterus saloumoides) and its response to bacterial challenge
Fc receptors (FcRs), specific to the Fc portion of immunoglobulin (Ig), are required to regulate immune responses against pathogenic infections....
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Initiating, innovating and accelerating edible cities. A case study based on two transition experiments in the city of Dresden (Germany)
Civic transition experiments targeting sustainable food production increasingly engage with edible cities aiming at providing free food on public...
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Testing Ballast Water Management Systems: Challenge Water Conditions During More Than 100 Test Voyages
Ballast water management systems (BWMS) are rigorously tested in land-based and shipboard settings, according to requirements outlined in the former...
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Functional properties of ant queen pheromones as revealed by behavioral experiments
An ant colony is the epitome of social organization where up to millions of individuals cooperate to survive, compete, and reproduce as a single...
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Transcriptional changes in the peripheral blood leukocytes from Brangus cattle before and after tick challenge with Rhipicephalus australis
BackgroundDisease emergence and production loss caused by cattle tick infestations have focused attention on genetic selection strategies to breed...
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3DVizSNP: a tool for rapidly visualizing missense mutations identified in high throughput experiments in iCn3D
BackgroundHigh throughput experiments in cancer and other areas of genomic research identify large numbers of sequence variants that need to be...
