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Replication stress as a driver of cellular senescence and aging
Replication stress refers to slowing or stalling of replication fork progression during DNA synthesis that disrupts faithful copying of the genome....
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Cellular Responses Against Abiotic Stress-Induced Reactive Oxygen Species
This chapter explores molecular mechanisms underlying behind molecular pathways triggered by excessive reactive oxygen species (ROS) production due...
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Oxidative Stress Triggered Damage to Cellular Biomolecules
Over-production of reactive oxygen species (ROS) within plant cell on the perception of abiotic and biotic stress is an inescapable phenomenon. The...
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Interplay of oxidative stress, cellular communication and signaling pathways in cancer
Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized...
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MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
FOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various...
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Molecular Mechanisms Underpinning Plant Stress Responses: Insights into the Cellular and Systemic Regulation
Plants are under constant environmental stress including extreme temperature, salinity, drought as well as insect and pathogen problems, which affect...
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Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?
Recent findings show that single, non-neuronal cells are also able to learn signalling responses develo** cellular memory. In cellular learning...
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Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence
Nuclear decoupling and softening are the main cellular mechanisms to resist mechanical stress-induced nuclear/DNA damage, however, its molecular...
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Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress
Sigma-1 receptor (S1R) is a calcium-sensitive, ligand-operated receptor chaperone present on the endoplasmic reticulum (ER) membrane. S1R plays an...
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Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer
SETβ is the predominant isoform of oncoprotein SE translocation (SET) in various breast cancer cell lines. Interactome-transcriptome analysis has...
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Cellular Response and Molecular Functions in Plants Under Abiotic Stress
The main objective of this chapter is to gain an understanding of how plants respond to abiotic stress by studying the response of Arabidopsis...
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Senescence and Apoptosis: ROS Contribution to Stress Tolerance or Cellular Impairment
Senescence and apoptosis are crucial developmental processes that take place during plant growth and development. Senescence is a genetically...
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Seed Priming with Gibberellic Acid and Ethephon Improved Rice Germination under Drought Stress via Reducing Oxidative and Cellular Damage
Gibberellic acid (GA) and ethephon (ETH) can stimulate seed germination and seedling growth. However, uncertainties persist concerning the efficacy...
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Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress
BackgroundThe mammalian oviduct is a complex, fibromuscular organ known for its role in orchestrating a series of timely and dynamic changes to...
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Cellular Senescence
Cellular senescence was first defined as replicative senescence after the works of Hayflick. Later this concept was extended to many other pathways...
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Severe cellular stress drives apoptosis through a dual control mechanism independently of p53
For past two decades, p53 has been claimed as the primary sensor initiating apoptosis. Under severe cellular stress, p53 transcriptional activity...
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Multi-omics analysis revealed that the protein kinase MoKin1 affected the cellular response to endoplasmic reticulum stress in the rice blast fungus, Magnaporthe oryzae
BackgroundPrevious studies have shown that protein kinase MoKin1 played an important role in the growth, conidiation, germination and pathogenicity...
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Muscle stem cell adaptations to cellular and environmental stress
BackgroundLifelong regeneration of the skeletal muscle is dependent on a rare population of resident skeletal muscle stem cells, also named...
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A burns and COVID-19 shared stress responding gene network deciphers CD1C-CD141- DCs as the key cellular components in septic prognosis
Differential body responses to various stresses, infectious or noninfectious, govern clinical outcomes ranging from asymptoma to death. However, the...
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Abiotic Stress
Since plants grow and reproduce in complex environmental conditions composed of a multitude of abiotic and biotic factors, they are frequently...