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Biotechnological approaches for the production of camptothecin
AbstractCamptothecin (CPT), an indole alkaloid popular for its anticancer property, is considered the third most promising drug after taxol and...
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Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition
Topoisomerase I (TOP1) controls the topological state of DNA during DNA replication, and its dysfunction due to treatment with an inhibitor, such as...
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Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer
To explore highly selective targeting molecules of colorectal cancer (CRC) is a challenge. We previously identified a twelve-amino acid peptide...
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Bioprocesses optimization and anticancer activity of camptothecin from Aspergillus flavus, an endophyte of in vitro cultured Astragalus fruticosus
BackgroundEmerging of endophytic fungi as potent camptothecin producers raise the hope for its commercial production, due to their rapid growth and...
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Biotechnology for micropropagation and camptothecin production in Ophiorrhiza sp.
AbstractCamptothecin (CPT) is a monoterpenoid-alkaloid, an anticancer compound from plant. Ever since its discovery in 1996 from the bark of Camptothe...
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Feedback regulation of salicylic acid signaling by isochorismate synthase1 modulates camptothecin biosynthesis in Camptotheca acuminata
Salicylic acid (SA) signaling regulates specialized metabolite biosynthesis in plants, including camptothecin (CPT) accumulation. Previous works have...
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Biotechnology of camptothecin production in Nothapodytes nimmoniana, Ophiorrhiza sp. and Camptotheca acuminata
Cancer is probably the deadliest human disease in recent years. In the past few years, rapid clinical progress has been made in the field of...
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Plant Cell Biofactories as In Vitro Production Platforms of the Anticancer Drug Camptothecin
Plants have been a treasure trove for products traditionally used in healthcare from time immemorial. Their contribution to the pharmaceutical,...
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The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila
The limited bioavailability of plant-derived natural products with anticancer activity poses major challenges to the pharmaceutical industry. An...
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Genome-wide survey of the GATA gene family in camptothecin-producing plant Ophiorrhiza pumila
BackgroundOphiorrhiza pumila (Rubiaceae) is capable of producing camptothecin (CPT), one monoterpene indole alkaloid extensively employed in the...
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Etoposide and Camptothecin Reduce Growth, Viability, the Generation of Petite Mutants, and Recognize the Active Site of DNA Topoisomerase I and II Enzymes in Candida glabrata
Candidemia, one of the most common invasive fungal infections in hospitalized patients, can lead to death and huge financial losses. Candida albicans ...
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Biomass and camptothecin production in the calcium chloride elicited and liquid medium overlayed Nothapodytes nimmoniana (J. Graham) Mabberly callus cultures
Nothapodytes nimmoniana (Icacinaceae) is an endangered medicinal plant species and a convenient source for the large-scale isolation of anti-cancer...
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Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
BackgroundThe anticancer drug camptothecin (CPT), first isolated from Camptotheca acuminata , was subsequently discovered in unrelated plants,...
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Variation in seedling vigour and camptothecin content of Pyrenacantha volubilis Wight: insights for domestication
As a pioneering work in the field of domestication of Pyrenacantha volubilis Wight, an anti-cancer drug (camptothecin) yielding plant, this study...
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Pyrazinamide Analogs Designed for Rational Drug Designing Strategies Against Resistant Tuberculosis (A Review)
Abstract–Several natural products extracted from trees exhibit significant anti-cancer activity. However, the efficacy of these products varies...
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Growth inhibition of Spodoptera frugiperda larvae by camptothecin correlates with alteration of the structures and gene expression profiles of the midgut
BackgroundSpodoptera frugiperda is a serious pest that causes devastating losses to many major crops, including corn, rice, sugarcane, and peanut....
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Heterologous overexpression of Nothapodytes foetida strictosidine synthase enhances levels of anti-cancer compound camptothecin in Ophiorrhiza rugosa
Nothapodytes foetida, an endangered tree of Indian origin, is a major source of the anti-cancer monoterpenoid indole alkaloid, camptothecin (CPT)....
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Activated charcoal: an effective enhancer of in vitro seed germination and growth in Nothapodytes foetida—a threatened medicinal plant
Nothapodytes foetida , ( N. foetida ) an endangered medicinal plant is a good source of camptothecin, an anti-cancer compound. Due to its indiscriminate...
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Nanotechnological Modus Operandi for the Delivery of Cytotoxic Phytochemicals
To treat various forms of cancer, a variety of pharmacological classes of drugs are available. Researchers are currently focusing their efforts on...
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Highly Purified Top1-Bound DNA Fragments
Topoisomerase 1–DNA cleavage complexes (Top1ccs) form at DNA sites of Top1 activity and are increased by a highly specific anticancer drug...