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Nanotechnological Modus Operandi for the Delivery of Cytotoxic Phytochemicals

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Bioprospecting of Tropical Medicinal Plants

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Abstract

To treat various forms of cancer, a variety of pharmacological classes of drugs are available. Researchers are currently focusing their efforts on develo** medications at the nanoscale level in order to improve target specificity and promote cytotoxicity at lower drug concentrations to minimize associated adverse effects. Natural chemicals derived from medicinal plants are thought to be attractive candidates for anticancer medication development. Since the last several decades, medicinal plants are screened for their cytotoxic profile. Vinca alkaloids, camptothecin, podophyllotoxin, taxanes and anthracyclines are examples of strong anticancer drugs that have been extracted from plant sources. For improved cancer therapy and management, nanotechnology-driven customized pharmaceuticals and drug delivery systems are being developed and launched into the market with positive outcomes. Drug delivery to cancer cells can be improved by using nanoparticulate drug carriers, which can lengthen drug half-lives in the blood, reduce side effects in non-target organs and concentrate drugs at the target sites. This book chapter will discuss various nanotechnological approaches to deliver phytochemicals in a variety of cancers.

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

    Thomson Alex & Yasmin Sultana

  2. KIET Group of Institution, KIET Group of Pharmacy, Ghaziabad, Uttar Pradesh, India

    Alankar Shrivastava

  3. Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India

    Damanpreet Kaur Lang

  4. Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India

    Rakhi Khabiya & Sweta S. Koka

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  1. Thomson Alex
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  2. Alankar Shrivastava
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  3. Damanpreet Kaur Lang
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  4. Rakhi Khabiya
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  5. Sweta S. Koka
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  6. Yasmin Sultana
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Correspondence to Yasmin Sultana .

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Editors and Affiliations

  1. Center for Studies in Stem Cells Cell Therapy and Toxicological Genetics (CeTroGen), Graduate Program in Health and Development in the Midwest RegionFaculty of Medicine (FAMED)Federal University of Mato Grosso do Sul (UFMS) Campo Grande, Cidade Universitária, Pioneiros, Mato Grosso do Sul, Brazil

    Karuppusamy Arunachalam

  2. Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Kunming, Yunnan, China

    Xuefei Yang

  3. Department of Botany, NSS College Nemmara, Palakkad, Kerala, India

    Sreeja Puthanpura Sasidharan

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Alex, T., Shrivastava, A., Lang, D.K., Khabiya, R., Koka, S.S., Sultana, Y. (2023). Nanotechnological Modus Operandi for the Delivery of Cytotoxic Phytochemicals. In: Arunachalam, K., Yang, X., Puthanpura Sasidharan, S. (eds) Bioprospecting of Tropical Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-031-28780-0_57

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