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Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming
Metabolic reprogramming is one of the main characteristics of cancer cells and plays pivotal role in the proliferation and survival of cancer cells....
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4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara
IntroductionCardiac dysfunction after sepsis the most common and severe sepsis-related organ failure. The severity of cardiac damage in sepsis...
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Taurine amino acid supplementation impacts performance, blood hematology, oxidative stress, and jejunum morphology in broiler chickens
Excess levels of free radicals cause oxidative damage to cells. Taurine is a rare amino acid with antioxidant effects whose dietary deficiency...
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Ancestral Sequence Reconstruction of the Ribosomal Protein uS8 and Reduction of Amino Acid Usage to a Smaller Alphabet
Understanding the origin and early evolution of proteins is important for unveiling how the RNA world developed into an RNA–protein world. Because...
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A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch
Lactic acidosis is a feature of solid tumors and plays fundamental role(s) rendering cancer cells to adapt to diverse metabolic stresses, but the...
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Amino acid utilization allows intestinal dominance of Lactobacillus amylovorus
The mammalian intestine harbors heterogeneous distribution of microbes among which specific taxa (e.g. Lactobacillus ) dominate across mammals....
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Interactive effects of dietary leucine and isoleucine affect amino acid profile and metabolism through AKT/TOR signaling pathways in blunt snout bream (Megalobrama amblycephala)
The purpose of this research is to explore the interaction between dietary leucine and isoleucine levels on whole-body composition, plasma and liver...
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Amino Acid Specificity of Ancestral Aminoacyl-tRNA Synthetase Prior to the Last Universal Common Ancestor Commonote commonote
Extant organisms commonly use 20 amino acids in protein synthesis. In the translation system, aminoacyl-tRNA synthetase (ARS) selectively binds an...
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Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study
IntroductionAlzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. Blood is frequently used as a source...
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Ancestral Sequence Reconstruction and Alternate Amino Acid States Guide Protein Library Design for Directed Evolution
Engineered proteins possess nearly limitless possibilities in medical and industrial applications but finding a precise amino acid sequence for these...
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Bayesian Cross-Validation Comparison of Amino Acid Replacement Models: Contrasting Profile Mixtures, Pairwise Exchangeabilities, and Gamma-Distributed Rates-Across-Sites
Models of amino acid replacement are central to modern phylogenetic inference, particularly so when dealing with deep evolutionary relationships....
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Nitrogen fertilization enhances growth and development of Cacopsylla chinensis by modifying production of ferulic acid and amino acids in pears
Psyllids feed exclusively on plant sap, which is an unbalanced diet for herbivores due to its low nitrogen content. Therefore, the...
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Characterization of the antioxidant and angiotensin I-converting enzyme inhibitory activities of lizardfish Saurida wanieso viscera sauce and their correlation with the amino acid profiles
The biological activities of lizardfish viscera sauce under three different fermentation conditions were characterized, and the amino acid profiles...
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A complete inventory of long-chain polyunsaturated fatty acid biosynthesis pathway enzymes in the miniaturized cyprinid Paedocypris micromegethes
The capacity for long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis activity in a species depends on the enzymatic activities of fatty...
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Delineation of the CYP505E subfamily of fungal self-sufficient in-chain hydroxylating cytochrome P450 monooxygenases
AbstractCytochrome P450 monooxygenases (CYP450s) are abundant in eukaryotes, specifically in plants and fungi where they play important roles in the...
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Superoxide Anion Radical Generation in Photosynthetic Electron Transport Chain
AbstractThis review analyzes data available in the literature on the rates, characteristics, and mechanisms of oxygen reduction to a superoxide anion...
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Molecular targets for antifungals in amino acid and protein biosynthetic pathways
Fungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary...
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Sarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes
IntroductionAlthough sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated....
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Structural insights into branch site proofreading by human spliceosome
Selection of the pre-mRNA branch site (BS) by the U2 small nuclear ribonucleoprotein (snRNP) is crucial to prespliceosome (A complex) assembly. The...
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The Amino Acid Transporter OsAAP4 Contributes to Rice Tillering and Grain Yield by Regulating Neutral Amino Acid Allocation through Two Splicing Variants
BackgroundAmino acids, which are transported by amino acid transporters, are the major forms of organic nitrogen utilized by higher plants. Among the...
