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FunBGC: An Intelligent Framework for Fungal Biosynthetic Gene Cluster Identification
Biosynthetic gene clusters (BGCs) in bacterial and fungal genomes encode bioactive secondary metabolites, which play a crucial role in many...
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Biosynthetic Gene Cluster Analysis in Actinobacterial Genus Streptomyces
Secondary metabolites offer a wide variety of biologically active compounds with great potential in medicine, agriculture, or livestock. With the...
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Remarkable enhancement of bleomycin production through precise amplification of its biosynthetic gene cluster in Streptomyces verticillus
Amplification of biosynthetic gene clusters is important to increase secondary metabolite production. However, the copy number of amplified gene...
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Biosynthetic pathway of peucemycin and identification of its derivative from Streptomyces peucetius
AbstractStreptomyces peucetius ATCC 27952 is a well-known producer of important anticancer compounds, daunorubicin and doxorubicin. In this study,...
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Amino acid (acyl carrier protein) ligase-associated biosynthetic gene clusters reveal unexplored biosynthetic potential
This study aimed to evaluate the postulated cellular function of a novel family of amino acid (acyl carrier protein) ligases (AALs) in natural...
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Manipulation and epigenetic control of silent biosynthetic pathways in actinobacteria
Most biosynthetic gene clusters (BGCs) of Actinobacteria are either silent or expressed less than the detectable level. The non-genetic approaches...
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Biogeographic patterns of biosynthetic potential and specialized metabolites in marine sediments
While the field of microbial biogeography has largely focused on the contributions of abiotic factors to community patterns, the potential influence...
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Biosynthetic pathways of triterpenoids and strategies to improve their Biosynthetic Efficiency
“Triterpenoids” can be considered natural products derived from the cyclization of squalene, yielding 3-deoxytriterpenes (hydrocarbons) or...
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In silico prediction of polyketide biosynthetic gene clusters in the genomes of Hypericum-borne endophytic fungi
BackgroundThe search for new bioactive natural compounds with anticancer activity is still of great importance. Even though their potential for...
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Genome mining of Bacillus licheniformis MCC2514 for the identification of lasso peptide biosynthetic gene cluster and its characterization
The probiotic strain Bacillus licheniformis MCC2514 has been shown to produce a strong antibacterial peptide and the whole genome sequence of this...
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Biosynthesis of the nucleoside antibiotic angustmycins: identification and characterization of the biosynthetic gene cluster reveal unprecedented dehydratase required for exo-glycal formation
The nucleoside antibiotic angustmycin, produced by some Streptomyces strains, is composed of adenine and C 6 sugar and shows antibiotic and antitumor...
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Biosynthetic gene clusters with biotechnological applications in novel Antarctic isolates from Actinomycetota
AbstractActinomycetota have been widely described as valuable sources for the acquisition of secondary metabolites. Most microbial metabolites are...
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Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer
BackgroundFungi are important sources for bioactive compounds that find their applications in many important sectors like in the pharma-, food- or...
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Unveiling biosynthetic potential of an Arctic marine-derived strain Aspergillus sydowii MNP-2
BackgroundA growing number of studies have demonstrated that the polar regions have the potential to be a significant repository of microbial...
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Genome-resolved metagenomics of Venice Lagoon surface sediment bacteria reveals high biosynthetic potential and metabolic plasticity as successful strategies in an impacted environment
Bacteria living in sediments play essential roles in marine ecosystems and deeper insights into the ecology and biogeochemistry of these largely...
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Investigation of chetomin as a lead compound and its biosynthetic pathway
AbstractChaetomium fungi produce a diversity of bioactive compounds. Chaetomium cochliodes SD-280 possesses 91 secondary metabolite gene clusters...
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The Capsicum terpenoid biosynthetic module is affected by spider-mite herbivory
In response to herbivory, Capsicum annuum leaves adapt their specialized metabolome that may protect the plant against herbivore feeding either...
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A Multi-Label Learning Framework for Predicting Chemical Classes and Biological Activities of Natural Products from Biosynthetic Gene Clusters
Natural products (NP) or secondary metabolites, as a class of small chemical molecules that are naturally synthesized by chromosomally clustered...
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Exploring the biosynthetic gene clusters in Brevibacterium: a comparative genomic analysis of diversity and distribution
Exploring Brevibacterium strains from various ecosystems may lead to the discovery of new antibiotic-producing strains. Brevibacterium sp. H-BE7, a...
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Biosynthetic Gene Cluster Analysis in Micromonospora Species Using ANTISMASH: Secondary Metabolite Genome Mining Pipeline
Micromonospora is a prolific producer of antibiotics. Producing more than about 700 antibiotic compounds, Micromonospora has received much attention...