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Transcription factor expression landscape in Drosophila embryonic cell lines
BackgroundTranscription factor (TF) proteins are a key component of the gene regulatory networks that control cellular fates and function. TFs bind...
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Analysis of Single-Cell Transcriptome Data in Drosophila
The fly Drosophila is a versatile model organism that has led to fascinating biological discoveries. In the past few years, Drosophila researchers...
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Delayed discovery of Hsp60 and subsequent characterization of moonlighting functions of multiple Hsp60 genes in Drosophila: a personal historical perspective
The pioneering studies carried out on heat shock-induced synthesis of specific proteins in the early 1970s did not identify any Hsp60 family protein...
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Using FlyBase: A Database of Drosophila Genes and Genetics
Since 1992, FlyBase has provided a freely available online database of information about the model organism Drosophila melanogaster. Data in FlyBase...
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Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues
Abstract —Regulation of retrotransposon activity in somatic tissues is a complex mechanism that has still not been studied in detail. It is strongly...
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SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis
SARS-CoV-2 infection causes COVID-19, a severe acute respiratory disease associated with cardiovascular complications including long-term outcomes....
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Comprehensive analysis of the COBRA-like (COBL) gene family through whole-genome analysis of land plants
COBRA-like genes play important roles in oriented cell division, cell expansion, cell wall biosynthesis, defense response, and tip-directed growth in...
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Drosophila melanogaster as a Model of Developmental Genetics: Modern Approaches and Prospects
AbstractFor more than a 100 years, the fruit fly Drosophila melanogaster has successfully served as a universal model in various genetic studies,...
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Research in China and International Research
The classic definition of epigenetics is “the study of changes in gene function that are heritable but do not entail a change in DNA sequence.” The...
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Molecular and cytological analysis of widely-used Gal4 driver lines for Drosophila neurobiology
BackgroundThe Drosophila central nervous system (CNS) is a convenient model system for the study of the molecular mechanisms of conserved...
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Identification of a novel intronic variant of ATP6V0A2 in a Han-Chinese family with cutis laxa
BackgroundCutis laxa is a connective tissue disease caused by abnormal synthesis or secretion of skin elastic fibers, leading to skin flabby and...
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Characterization and Genome Analysis of a Novel Mu-like Phage VW-6B Isolated from the Napahai Plateau Wetland of China
Although bacteriophages are more numerous and have smaller genomes than their bacterial hosts, relatively few have their genomes sequenced. Here, we...
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Expression of Staphylococcus aureus translation elongation factor P is regulated by a stress-inducible promotor
Translation elongation factor P, expressed by the efp gene, is a conserved protein closely related to bacterial virulence and environmental stress...
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scDALI: modeling allelic heterogeneity in single cells reveals context-specific genetic regulation
While it is established that the functional impact of genetic variation can vary across cell types and states, capturing this diversity remains...
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Regulatory gene function handoff allows essential gene loss in mosquitoes
Regulatory genes are often multifunctional and constrained, which results in evolutionary conservation. It is difficult to understand how a...
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Induced Mutations for Development of New Cultivars and Molecular Analysis of Genes in Japan
Mutation breeding was accelerated in Japan following the construction of the Gamma Field in 1960. There are 332 direct-use mutant cultivars generated...
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Chemical–Genetic Interactions as a Means to Characterize Drug Synergy
The combination of model organisms and comprehensive genome-wide screens has provided a wealth of data into the structure and regulation of the...
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Reproductive consequences of an extra long-term sperm storage organ
BackgroundSperm storage plays a key role in the reproductive success of many sexually-reproducing organisms, and the capacity of long-term sperm...
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Role of tbc1 in Drosophila embryonic salivary glands
BackgroundCG4552/tbc1 was identified as a downstream target of Fork head (Fkh), the single Drosophila member of the FoxA family of transcription...
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Tutorial: An Overview of Important Databases and Programs
The tutorials are designed to walk you through important analysis steps and associated software that appear in the book, so that you learn to do the...