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Anticancer potential and structure activity studies of purine and pyrimidine derivatives: an updated review
Cancer is the world’s leading cause of death impacting millions of lives globally. The increasing research over the past several decades has focused...
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An efficient methodological approach for synthesis of selenopyridines: generation, reactions, anticancer activity, EGFR inhibitory activity and molecular docking studies
In the present work, we successfully synthesized Se -alkyl selenopyridines 1 and 3 , selenopheno[2,3- b ]pyridine 2 , and bis-selenopyridine 4 derivatives...
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Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species
Indole alkaloids, predominantly found in plants, are a large group of natural product-derived compounds characterized by a remarkable chemical...
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Microwave-Assisted Triflic Anhydride Mediated Mild and Efficient Method for the Synthesis of Novel Enamine Functionalized Benzothiophene Derivatives and Their Anticancer Activity
AbstractA series of triflic anhydride mediated novel enamine functionalized benzothiophene derivatives were designed, synthesized by...
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Screening for Anticancer Activity: Dual Staining Method
Tumor is one of the most significant concerns worldwide. Recent studies have disclosed that through different pathways, bacterial extracts exhibit...
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Anticancer activity, DFT study, ADMET prediction, and molecular docking of novel α-sulfamidophosphonates
A series of novel α-sulfamidophosphonate derivatives ( 3a-3 g ) were synthesized and evaluated for anticancer activity against different human cancer...
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Screening for Anticancer Activity: DNA Fragmentation Assay
Cancer is the world’s second major cause of death, and despite significant advances in drug distribution, bacteria-based therapies still need to be...
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Cucurbitacin-I exhibits anticancer activity by inducing apoptosis in SKOV3 human ovarian cancer cells
BackgroundCucurbitacin-I is a natural cell-permeable triterpenoid compound isolated from Cucurbitaceae and Cruciferae. The pharmacological activity...
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Antioxidant, Anticancer, Hepatoprotective and Wound Healing Activity of Fucopyranose (Sulfated Polysaccharides) from Padina pavonica (L.)
The emergence of various diseases such as cardiovascular, aging and cancer are due to oxidative stress as well as the shortage of enough antioxidant...
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Synthesis, Computational Insights, and Anticancer Activity of Novel Indole–Schiff Base Derivatives
AbstractSynthetic and naturally available compounds with indole moiety are known to show significant biological activity. This paper describes...
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Two Recombinant Bacteriocins, Rhamnosin and Lysostaphin, Show Synergistic Anticancer Activity Against Gemcitabine-Resistant Cholangiocarcinoma Cell Lines
Cholangiocarcinoma (CCA), a bile duct cancer with a high mortality rate, has a poor prognosis due to its highly invasive and drug-resistant...
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Potent anticancer activity of a novel iridium metallodrug via oncosis
Oncosis (from Greek ónkos , meaning “swelling”) is a non-apoptotic cell death process related to energy depletion. In contrast to apoptosis, which is...
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Rationally designed PMAP-23 derivatives with enhanced bactericidal and anticancer activity based on the molecular mechanism of peptide–membrane interactions
Antimicrobial peptides (AMPs) are a crucial component of the natural defense system that the host employs to protect itself against invading...
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Screening for Anticancer Activity: Neutral Red Uptake Assay
Presently, in vitro cytotoxicity experiments used in the developmental phases of the exploration of anticancer agents are capable of selecting the...
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Phytochemical Analysis, Antioxidant, Antimicrobial and Anticancer Activity of Nigella sativa and Oroxylum indicum
Medicinal plants are traditionally being used by various communities for curing several ailments. Two plants namely Nigella sativa and Oroxylum indicum ...
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Anticancer activity features of imidazole-based ionic liquids and lysosomotropic detergents: in silico and in vitro studies
Long-chain imidazole-based ionic liquids (compounds 2, 4, 9) and lysosomotropic detergents (compounds 7, 3, 8) with potent anticancer activity were...
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CADD Approaches in Anticancer Drug Discovery
To this day, cancer remains one of the leading killers worldwide. Major breakthroughs in cancer research have been made over the past four decades,...
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Exploration of 2-(Substituted Phenyl)-thiazolidin-4-one as Anticancer Agents
AbstractA facile synthesis of (2-(substituted phenyl)-thiazolidin-4-one by using recyclable catalyst β-cyclodextrinSO 3 H has been achieved. It has...
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Rational synthesis, anticancer activity, and molecular docking studies of novel benzofuran liked thiazole hybrids
A novel series of benzofuran bearing thiazole hybrids were synthesized by the multistep reaction approach. All synthesized molecules were selected by...
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Synthesis and screening for anticancer activity of two novel telluro-amino acids: 1,3-Tellurazolidine-4-carboxylic acid and tellurohomocystine
Tellurium (Te) containing amino acids and their derivatives have the potential to participate in biological processes, which are currently being...
