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Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence
Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer’s disease (AD). Previous evidence suggested disruptions of multiple...
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The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy
BackgroundStandard neuropathologic analysis of Alzheimer’s brain relies on traditional fluorescence microscopy, which suffers from limited spatial...
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Light Microscopy Approach for Simultaneous Identification of Glial Cells and Amyloid Plaques
AbstractThe close spatial relationship of glial cells (astroglia and microglia) to amyloid plaques is one of the histopathological features of...
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Preparation of near-infrared AIEgen-active fluorescent probes for map** amyloid-β plaques in brain tissues and living mice
Fibrillar aggregates of the amyloid-β protein (Aβ) are the main component of the senile plaques found in brains of patients with Alzheimer’s disease...
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Modelling of Anti-amyloid-Beta Therapy for Alzheimer’s Disease
A healthy brain clears different types of debris with the help of specialized glial cells. These cells contiguously tile the entire central nervous...
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A fragment of cell adhesion molecule L1 reduces amyloid-β plaques in a mouse model of Alzheimer’s disease
Deposition of amyloid-β (Aβ) in the brain is one of the important histopathological features of Alzheimer’s disease (AD). Previously, we reported a...
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Pre-clinical evaluation of 99mTc-labeled chalcone derivative for amyloid-β imaging post-head trauma
Aβ 42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most...
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Role of Interaction between Zinc and Amyloid Beta in Pathogenesis of Alzheimer’s Disease
AbstractProgression of Alzheimer’s disease is accompanied by the appearance of extracellular deposits in the brain tissues of patients with...
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APPswe/PS1dE9/Blg Transgenic Mouse Line for Modeling Cerebral Amyloid Angiopathy Associated with Alzheimer’s Disease
AbstractAlzheimer’s disease (AD) is the most common proteinopathy, which is accompanied by a steady decrease in the patient’s cognitive functions...
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Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels
Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object...
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M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue
Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer’s disease (AD). However, proficient methods to detect...
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Acetylcholine hydrolytic activity of fibrillated β-amyloid (1–40) peptide
Alzheimer's disease is characterized by the presence of senile plaques composed of β-amyloid peptide (Aβ) aggregates with toxic effects that are...
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Increased α-2,6 sialic acid on microglia in amyloid pathology is resistant to oseltamivir
Terminal sialic acid residues are present on most glycoproteins and glycolipids, but levels of sialylation are known to change in the brain...
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Amyloid beta accumulation in TgF344-AD rats is associated with reduced cerebral capillary endothelial Kir2.1 expression and neurovascular uncoupling
Alzheimer’s disease (AD) exerts a tremendous socio-economic burden worldwide. Although reduced cerebral blood flow is an early and persistent symptom...
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Unveiling the mechanistic link between extracellular amyloid fibrils, mechano-signaling and YAP activation in cancer
The tumor microenvironment is a complex ecosystem that plays a critical role in cancer progression and treatment response. Recently, extracellular...
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Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the...
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Bioactive Peptides of Fermented Food Products Targeting the Structural Rigid Core of Amyloid Fibril Unravelled by Simulated Thermal Unfolding in Alzheimer’s Disorder
Amyloid fibril aggregation is an integral pathogenic constituent behind Alzheimer’s disorder (AD). Drawbacks in current AD medication warrant a...
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Zinc and pH modulate the ability of insulin to inhibit aggregation of islet amyloid polypeptide
Aggregation of the human islet amyloid polypeptide (hIAPP) contributes to the development and progression of Type 2 Diabetes (T2D). hIAPP aggregates...
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Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils
Many proteins self-assemble to form amyloid fibrils, which are highly organized structures stabilized by a characteristic cross-β network of hydrogen...
