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Determination of Differential Alternative Splicing Under Stress Conditions
Alternative splicing (AS) is an important mechanism contributing to stress-induced regulation of gene expression and proteome diversity. Massive...
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Splicing complexity as a pivotal feature of alternative exons in mammalian species
BackgroundAs a significant process of post-transcriptional gene expression regulation in eukaryotic cells, alternative splicing (AS) of exons greatly...
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Combining genetic constraint with predictions of alternative splicing to prioritize deleterious splicing in rare disease studies
BackgroundDespite numerous molecular and computational advances, roughly half of patients with a rare disease remain undiagnosed after exome or...
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Benchmarking splice variant prediction algorithms using massively parallel splicing assays
BackgroundVariants that disrupt mRNA splicing account for a sizable fraction of the pathogenic burden in many genetic disorders, but identifying...
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The physiology of alternative splicing
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. In this Review, we discuss...
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Alternative splicing analysis of lignocellulose-degrading enzyme genes and enzyme variants in Aspergillus niger
AbstractAlternative splicing (AS) greatly expands the protein diversity in eukaryotes. Although AS variants have been frequently reported existing in...
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Alternative splicing is not a key source of chemerin isoforms diversity
BackgroundChemerin is a chemoattractant protein with adipokine and antimicrobial properties encoded by the retinoic acid receptor responder 2 ( RARRES2...
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Resurrecting the alternative splicing landscape of archaic hominins using machine learning
Alternative splicing contributes to adaptation and divergence in many species. However, it has not been possible to directly compare splicing between...
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Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing
Talaromyces marneffei ( T. marneffei ) immune escape is essential in the pathogenesis of talaromycosis. It is currently known that T. marneffei ...
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Alternative Splicing of Pre-messenger RNA
Alternative splicing is a critical component of gene expression. Virtually all multiexon genes undergo alternative splicing. By combining the...
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TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms
Alternative splicing (AS) is a promising clinical target for cancer treatment at the post-transcriptional level. We previously identified a unique AS...
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Alternative splicing: a new breakthrough for understanding tumorigenesis and potential clinical applications
BackgroundAlternative splicing (AS) is a post-transcriptional process that produces transcript variants, thus leading to transcriptome complexity....
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Alternative splicing shapes the transcriptome complexity in blackgram [Vigna mungo (L.) Hepper]
Vigna mungo , a highly consumed crop in the pan-Asian countries, is vulnerable to several biotic and abiotic stresses. Understanding the...
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Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their...
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Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos
The heterogeneity of CARM1 controls first cell fate bias during early mouse development. However, how this heterogeneity is established is unknown....
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Insights into sweet potato SR proteins: from evolution to species-specific expression and alternative splicing
Main conclusionSR proteins from sweet potato have conserved functional domains and similar gene structures as that of Arabidopsis and rice in...
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Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells
Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity. However, the molecular mechanisms underlying the origin of...
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c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance
Acute megakaryocytic leukemia (AMKL) is a clinically heterogeneous subtype of acute myeloid leukemia characterized by unrestricted megakaryoblast...
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SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52
Many studies have proven that splicing factors are crucial for human malignant tumor development. However, as a classical splicing factor, the...
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Comprehensive analysis of pre-mRNA alternative splicing regulated by m6A methylation in pig oxidative and glycolytic skeletal muscles
BackgroundDifferent types of skeletal myofibers exhibit distinct physiological and metabolic properties that are associated with meat quality traits...
