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Metabolomics of early myocardial ischemia
IntroductionDiagnosing myocardial infarction is difficult during the initial phase. As, acute myocardial ischemia is associated with changes in...
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Autosis: a new form of cell death in myocardial ischemia–reperfusion injury
Cardiomyocytes undergo a variety of cell death events during myocardial ischemia‒reperfusion injury (MIRI). Understanding the causes of cardiomyocyte...
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The interplay between T lymphocytes and macrophages in myocardial ischemia/reperfusion injury
Acute myocardial infarction is one of the most important causes of death in the world, causing a huge health and economic burden to the world. It is...
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MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia–reperfusion injury
MicroRNAs are single-stranded non-coding RNAs that participate in post-transcriptional regulation of gene expression, it is involved in the...
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The Initial Autonomic Tone Determines the Progress of Irreversible Myocardial Ischemia in Rats
AbstractThe HRV analysis in rats was used to evaluate the relationship between the initial level of total HRV and regulatory changes in the heart...
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Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1
Myocardial ischemia/reperfusion (I/R) injury is a complex pathological process that is still not fully understood. The oxidative stress response has...
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Myocardial Electrophysiological Response to Ischemia and Reperfusion Depends on the Age of Rats
AbstractAge is a major driver of the risk of acute myocardial infarction and malignant ventricular arrhythmias. However, age-related changes in the...
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AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury
Aging leads to the threat of more diseases to the biological anatomical structure and the decline of disease resistance, increasing the incidence and...
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Modeling acute myocardial infarction and cardiac fibrosis using human induced pluripotent stem cell-derived multi-cellular heart organoids
Heart disease involves irreversible myocardial injury that leads to high morbidity and mortality rates. Numerous cell-based cardiac in vitro models...
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MiR-130a-3p regulates FUNDC1-mediated mitophagy by targeting GJA1 in myocardial ischemia/reperfusion injury
Understanding the complex pathogenesis in myocardial ischemia/reperfusion (I/R) injury (IRI) is an urgent problem in clinical trials. Increasing...
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MRTF-A alleviates myocardial ischemia reperfusion injury by inhibiting the inflammatory response and inducing autophagy
Myocardin-related transcription factor A (MRTF-A) has an inhibitory effect on myocardial infarction; however, the mechanism is not clear. This study...
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RETRACTED ARTICLE: Simvastatin-loaded nano-niosomes efficiently downregulates the MAPK-NF-κB pathway during the acute phase of myocardial ischemia-reperfusion injury
BackgroundSimvastatin can potentially mitigate acute inflammatory phase of myocardial ischemia-reperfusion injury. However, these effects negatively...
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The m6A methylation enzyme METTL14 regulates myocardial ischemia/reperfusion injury through the Akt/mTOR signaling pathway
Herein, we investigated the role of the m 6 A methylation enzyme METTL14 in regulating myocardial ischemia/reperfusion injury (IR/I) through the...
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Engineering of MSCs sheet for the prevention of myocardial ischemia and for left ventricle remodeling
Tissue engineering combines cell biology and material science to construct tissues or organs for disease modeling, drug testing, and regenerative...
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Upregulation of Hsp27 via further inhibition of histone H2A ubiquitination confers protection against myocardial ischemia/reperfusion injury by promoting glycolysis and enhancing mitochondrial function
Research suggests that ischemic glycolysis improves myocardial tolerance to anoxia and low-flow ischemia. The rate of glycolysis during ischemia...
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STUB1 is acetylated by KAT5 and alleviates myocardial ischemia-reperfusion injury through LATS2-YAP-β-catenin axis
Myocardial ischemia-reperfusion injury (MIRI) is involved in the pathogenesis of multiple cardiovascular diseases. This study elucidated the...
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The Effect and Mechanism of POSTN and Its Alternative Splicing on the Apoptosis of Myocardial Cells in Acute Myocardial Infarction: A Study in Vitro
Our study aimed to investigate key molecular targets in the pathogenesis of AMI, and provide new strategy for the treatment. In this work, the...
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RNA methylation reading protein YTHDF2 relieves myocardial ischemia–reperfusion injury by downregulating BNIP3 via m6A modification
BNIP3 is reported to be involved in hypoxia-induced mitochondrial defect and cell death in cardiomyocytes. However, little is known about the...
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Uncoupling protein 1 knockout aggravates isoproterenol-induced acute myocardial ischemia via AMPK/mTOR/PPARα pathways in rats
Uncoupling protein 1 (UCP1) was found exclusively in the inner membranes of the mitochondria of brown adipose tissue (BAT). We found that UCP1 was...
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Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia
BackgroundThere is a mutual hemodynamic and pathophysiological basis between the heart and brain. Glutamate (GLU) signaling plays an important role...
