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Synthesis and applications of cyclonucleosides: an update (2010–2023)
Cyclonucleosides are a group of nucleoside derivatives which, in addition to the classical N -glycosidic bond, have an additional covalent bond...
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Potential in vitro action of an adenosine analog and synergism with penicillin against Corynebacterium pseudotuberculosis
Caseous lymphadenitis is a well-known disease caused by Corynebacterium pseudotuberculosis affecting small ruminants with small significance to human...
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The Pollen Tube: A Model System for Cell and Molecular Biology Studies
Pollen tubes, the active male gametophytes of seed plants, are the vectors carrying the male sperm cells to the egg cell of the female gametophyte...
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Ions and Pollen Tube Growth
Ions play a crucial role in the control of pollen tube growth. In this review we focus on four that seem especially important: calcium (Ca...
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GnRH-driven FTO-mediated RNA m6A modification promotes gonadotropin synthesis and secretion
BackgroundGonadotropin precisely controls mammalian reproductive activities. Systematic analysis of the mechanisms by which epigenetic modifications...
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Zebrafish an experimental model of Huntington’s disease: molecular aspects, therapeutic targets and current challenges
AbstractHuntington disease (HD) is a lethal autosomal dominant neurodegenerative disease whose exact causative mechanism is still unknown. It can...
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Whole-Genome Sequencing of Plants: Past, Present, and Future
Advances in analytical chemistry, as well as the constant introduction of novel analytical chemistry approaches, are altering genomics at a higher...
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Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers
Voltage-gated calcium channels (VGCCs) are essential for transforming electrical signals such as action potentials into biochemical and eventually...
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Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasis
The downregulation of AMP-activated protein kinase (AMPK) activity contributes to numerous pathologies. Recent reports suggest that the elevation of...
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Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart
Leading-strand template aberrations cause helicase–polymerase uncoupling and impede replication fork progression, but the details of how uncoupled...
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EPAC Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part II. The role of EPAC Proteins in the Physiology and Pathology of the Heart
AbstractThe second part of the review presents modern ideas about vision of the role of Epac proteins in the regulation of inotropic and rhythmic...
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Assessment of soil potential to natural attenuation and autochthonous bioaugmentation using microarray and functional predictions from metagenome profiling
PurposeThe use of autochthonous microorganisms for the bioaugmentation of areas contaminated with hydrocarbons has a high potential to overcome the...
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Trying to Reveal the Mysteries of Stem Cells Using “Omics” Strategies
Owing to their self-renewal property and ability to differentiate toward various cell types of the human body, stem cells sound as an Utopian dream...
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Non-peptidyl small molecule, adenosine, 5′-Se-methyl-5′-seleno-, 2′,3′-diacetate, activates insulin receptor and attenuates hyperglycemia in type 2 diabetic Leprdb/db mice
The pathophysiology of type 2 diabetes mellitus (T2D) is characterized by reduced or absent insulin receptor (INSR) responsiveness to its ligand,...
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Characterization of an atypical, thermostable, organic solvent- and acid-tolerant 2′-deoxyribosyltransferase from Chroococcidiopsis thermalis
In our search for thermophilic and acid-tolerant nucleoside 2′-deoxyribosyltransferases (NDTs), we found a good candidate in an enzyme encoded by Chroo...
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2′-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases
Processes catalyzed by enzymes offer numerous advantages over chemical methods although in many occasions the stability of the biocatalysts becomes a...
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Effects of probiotic Bacillus as a substitute for antibiotics on antioxidant capacity and intestinal autophagy of piglets
The objective of this study was to evaluate effects of probiotic Bacillus amyloliquefaciens ( Ba ) as a substitute for antibiotics on growth...
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ATP-induced Ca2+-signalling mechanisms in the regulation of mesenchymal stem cell migration
The ability of cells to migrate to the destined tissues or lesions is crucial for physiological processes from tissue morphogenesis, homeostasis and...
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Cordyceps: A Highly Coveted Medicinal Mushroom
Traditional Chinese medicine (TCM) has a long history of using plant, animal, and fungal materials for their medicinal values. One of the better...
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An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum
BackgroundTranscriptional responses to small molecules can provide insights into drug mode of action (MOA). The capacity of the human malaria...
