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QSAR analysis of 3-pyrimidin-4-yl-oxazolidin-2-one derivatives isocitrate dehydrogenase inhibitors using Topomer CoMFA and HQSAR methods
AbstractA series of mIDH1 inhibitors derived from 3-pyrimidine-4-oxazolidin-2-ketone derivatives were studied by QSAR model to explore the key...
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Sources and control of impurity during one-pot enzymatic production of dehydroepiandrosterone
AbstractDehydroepiandrosterone (DHEA) has a promising market due to its capacity to regulate human hormone levels as well as preventing and treating...
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Parameters of Energy Metabolism and Adenylate System in Mytilus galloprovincialis Tissues under Moderate Hypoxia
AbstractThe effect of moderate hypoxia on the processes of energy metabolism was studied in the tissues (gills, hepatopancreas) of the Mediterranean...
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Strategy for the Identification of Host-Defense Peptides in Frog Skin Secretions with Therapeutic Potential as Antidiabetic Agents
Several amphibian peptides that were first identified on the basis of their antimicrobial or cytotoxic properties have subsequently shown potential...
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Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling
Acute liver failure (ALF) is a disease with a high mortality rate and poor prognosis, whose pathogenesis is not fully understood. PANoptosis is a...
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Nox5: Molecular Regulation and Pathophysiology
Nox5 is considered to be the precursor NADPH oxidase in the evolution of the Noxs and is the most ancient member of the Nox family. It is widely...
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Protective role of selenium and selenium-nanoparticles against multiple stresses in Pangasianodon hypophthalmus
Pollution and climate change pose significant threats to aquatic ecosystems, with adverse impacts on aquatic animals, including fish. Climate change...
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Field resistance to boscalid and molecular mechanisms of strawberry Botrytis cinerea in Chongqing, China
Gray mold is a common and severe disease that affects strawberry production and storage. To clarify the occurrence and mechanism of Botrytis cinerea ...
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Effect of ammonium stress on phosphorus solubilization of a novel marine mangrove microorganism Bacillus aryabhattai NM1-A2 as revealed by integrated omics analysis
BackgroundPhosphorus is one of the essential nutrients for plant growth. Phosphate-solubilizing microorganisms (PSMs) can alleviate available P...
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Expression of Synthetic cyp102A1-LG23 Gene and Functional Analysis of Recombinant Cytochrome P450 BM3-LG23 in the Actinobacterium Mycolicibacterium smegmatis
AbstractCytochrome CYP102A1 (P450 BM3) of Priestia megaterium (bas. Bacillus megaterium ) has several unique functional features and thus provides an...
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Rice Equivalent Yield and Soil Properties as Influenced by Conventional and Minimum Tillage System in Rice Based Crop** Sequence in North-East India
The minimum disturbance of soil is gaining popularity in different parts of the world because of definite advantages over conventional tillage (CT)...
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Cloning, heterologous expression, and functional characterization of a hydroxyphenylpyruvate reductase (HPPR) gene involved in rosmarinic acid biosynthesis in Prunella vulgaris
Rosmarinic acid (RA) and its derivatives have wide medicinal applications. However, the biosynthetic pathway of RA in Prunella vulgaris is still...
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Identification of a novel thermostable transaminase and its application in L-phosphinothricin biosynthesis
AbstractTransaminase (TA) is a crucial biocatalyst for enantioselective production of the herbicide L-phosphinothricin (L-PPT). The use of enzymatic...
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Rice Transcriptomics Reveal the Genetic Determinants of An In Planta Photorespiratory Bypass: a Novel Way to Increase Biomass in C3 Plants
Develo** C 4 rice is one of the global research challenges for yield improvement. In the optimal environment, the key difference between C 3 and C 4 ...
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Potato Growth Promotion Using an Ecological Phosphate Fertiliser Composed of the Phosphate-Solubilising Bacterium Pseudomonas rhizophila S211 and Natural Rock Phosphate
The use of mineral phosphorus solubilising (MPS) bacterial inoculants, alone or supplemented with rock phosphate (RP), supports sustainable...
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Phytosterol conversion into C9 non-hydroxylated derivatives through gene regulation in Mycobacterium fortuitum
AbstractAndrost-4-ene-3,17-dione (AD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) are important drug intermediates that can be biosynthesized...
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Effect of Intensification of the Tricarboxylic Acid Cycle on Biosynthesis of Adipic Acid Through the Inverted Fatty Acid β-Oxidation by Escherichia coli Strains
AbstractUsing the previously engineered adipate-secreting Escherichia MG1655 lacI Q , ∆ ackA-pta , ∆ poxB , ∆ ldhA , ∆ adhE , P L -SD φ 10 - atoB , P trc- ideal-4 -SD φ1 0 -...
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Biomass and enzymatic activities of marine bacteria in the presence of multiple metals
Marine environments are a repository for metals, and humans have enhanced this phenomenon over the years. Heavy metals are notoriously toxic due to...
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Production of 21-hydroxy-20-methyl-pregna-1,4-dien-3-one by modifying multiple genes in Mycolicibacterium
AbstractC22 steroid drug intermediates are suitable for corticosteroids synthesis, and the production of C22 steroids is unsatisfactory due to the...
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Cloning, Expression and Characterization of a Highly Active Alcohol Dehydrogenase for Production of Ethyl (S)-4-Chloro-3-Hydroxybutyrate
A novel alcohol dehydrogenase from Bartonella apis (BaADH) was heterologous expressed in Escherichia coli . Its biochemical properties were...
