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Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities
Two new chlorinated bis -indole alkaloids, dionemycin ( 1 ) and 6-OMe-7′,7″-dichorochromopyrrolic acid ( 2 ), along with seven known analogs 3 – 9 , were...
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Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032
Tryptophan dimers (TDs) are an important class of natural products with diverse bioactivities and share conserved biosynthetic pathways. We report...
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Antitumor Microbial Products by Actinomycetes Isolated from Different Environments
Chemotherapy is in many cases the primary treatment against several cancers. However, there has been increasing and uninterrupted resistance to...
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The Role of Iron Competition in the Antagonistic Action of the Rice Endophyte Streptomyces sporocinereus OsiSh-2 Against the Pathogen Magnaporthe oryzae
Rice blast caused by Magnaporthe oryzae severely impacts global rice yield stability. The rice endophyte Streptomyces sporocinereus OsiSh-2, with...
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In silico molecular docking, preclinical evaluation of spiroindimicins A-D, lynamicin A and D isolated from deep marine sea derived Streptomyces sp. SCSIO 03032
The criteria used for successful drug discovery involves high throughput screening for preclinical evaluation and its interaction with target...
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The unique chemistry and biology of the piericidins
The piericidin family of microbial metabolites features a 4-pyridinol core linked with a methylated polyketide side chain. Piericidins are...
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Bioactive Compounds from Marine Extremophiles
With the development of the self-contained underwater breathing apparatus (SCUBA) and other recently developed marine collecting techniques, numerous...
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Biotechnological Exploitation of Actinobacterial Members
Microbial-derived products, while do not have many environmental side effects of their synthetic counterparts, have proved more efficient than those...