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Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation
Thioredoxin interacting protein (Txnip) is a stress-responsive factor regulating Trx1 for redox balance and involved in diverse cellular processes...
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CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells
Current differentiation protocols for human induced pluripotent stem cells (hiPSCs) produce heterogeneous cardiomyocytes (CMs). Although...
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SOX9 inactivation affects the proliferation and differentiation of human lung organoids
BackgroundThe regulation of the transcription factor sex-determining region Y-box transcription factor 9 (SOX9) in lung development has been...
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Combinational Overexpression of Foxa3 and Hnf4a Enhance the Proliferation and Prolong the Functional Maintenance of Primary Hepatocytes
AbstractIn an in vitro culture system, primary hepatocytes usually display a low proliferation capacity, accompanied with a decrease of viability and...
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Enhanced osteogenic differentiation potential of Arnica montana and Bellis perennis in C3H10T1/2 multipotent mesenchymal stem cells
BackgroundArnica montana and Bellis perennis are two medicinal plants that are thought to accelerate bone repair in homoeopathic literature....
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PRC1 suppresses a female gene regulatory network to ensure testicular differentiation
Gonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In...
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Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that...
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Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease
Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation characterize vascular diseases causing heart attack and stroke. Here we...
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POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6
POU5F1 plays an important role in maintaining the cancer stem cell (CSC) -like properties of gastric cancer (GC) cells. The impact of POU5F1 on the...
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Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the...
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New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling
ObjectiveOsteoporosis is a global health issue characterized by decreased bone mass and microstructural degradation, leading to an increased risk of...
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Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis
BackgroundPrevious studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate...
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The role of semaphorin 3A on chondrogenic differentiation
Osteoblast-derived semaphorin3A (Sema3A) has been reported to be involved in bone protection, and Sema3A knockout mice have been reported to exhibit...
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CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation
CD4 + T helper (Th) cell differentiation is regulated by lineage-specific expression of transcription factors, which is tightly associated with...
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RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter
BackgroundMegakaryocytes (MKs) are platelet precursors, which arise from hematopoietic stem cells (HSCs). While MK lineage commitment and...
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The Impact of Mitochondria in Ovarian Cancer Cell Metabolism, Proliferation, and Metastasis
Mitochondrial dysfunctions are significantly implicated in cancer initiation, progression, and metastasis, which have been shown for several cancers...
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MiR-26b-5p/TET3 regulates the osteogenic differentiation of human bone mesenchymal stem cells and bone reconstruction in female rats with calvarial defects
BackgroundMicroRNAs (miRNAs) play critical roles in the osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs), but the mechanism...
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AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea
Mechanosensitive hair cells (HCs) in the cochlear sensory epithelium are critical for sound detection and transduction. Mammalian HCs in the cochlea...
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JUNB affects hair follicle development and regeneration by promoting the proliferation of dermal papilla cells in goat
BackgroundThe process of hair follicle morphogenesis, development, and regeneration essentially depends on the interaction between skin epidermis and...
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Enhanced therapeutic potential of Flotillins-modified MenSCs by improve the survival, proliferation and migration
Menstrual blood-derived endometrial stem cells (MenSCs) have attracted increasing interest due to their excellent safety, and lack of ethical dilemma...
