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Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression
Oxidative stress plays a pivotal role in the differentiation and proliferation of cells and programmed cell death. However, studies on the role of...
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Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
BackgroundNatural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral...
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A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma
BackgroundMalignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We...
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Osteogenic human MSC-derived extracellular vesicles regulate MSC activity and osteogenic differentiation and promote bone regeneration in a rat calvarial defect model
BackgroundThere is growing evidence that extracellular vesicles (EVs) play a crucial role in the paracrine mechanisms of transplanted human...
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USP18 is an essential regulator of muscle cell differentiation and maturation
The ubiquitin proteasomal system is a critical regulator of muscle physiology, and impaired UPS is key in many muscle pathologies. Yet, little is...
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Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development
The enzymes performing protein post-translational modifications (PTMs) form a critical post-translational regulatory circuitry that orchestrates...
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Transcriptome During Normal Cell Differentiation
This chapter provides a review of recent advances in understanding the importance of normal cell differentiation and the key regulators that...
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Small protein blockers of human IL-6 receptor alpha inhibit proliferation and migration of cancer cells
BackgroundInterleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of...
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Betaine regulates adipogenic and osteogenic differentiation of hAD-MSCs
BackgroundWith an ageing population, the incidence of bone loss and obesity are increasing. Numerous studies emphasized the multidirectional...
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ATP purinergic receptor signalling promotes Sca-1+ cell proliferation and migration for vascular remodelling
AimsVascular resident stem cells expressing stem cell antigen-1 (Sca-1 + cells) promote vascular regeneration and remodelling following injury...
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Anti-apoptotic protein Bcl-2 contributes to the determination of reserve cells during myogenic differentiation of C2C12 cells
Skeletal muscle's regenerative ability is vital for maintaining muscle function, but chronic diseases like Duchenne muscular dystrophy can deplete...
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Effect of magnesium oxide nanoparticles and LED irradiation on the viability and differentiation of human stem cells of the apical papilla
PurposeCurrently, regenerative endodontic treatments are gaining more and more attention, and stem cells play a significant role in these treatments....
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Osteogenic Differentiation Capacity of Dental Pulp Stem Cells on 3D Printed Polyurethane/Boric Acid Scaffold
Additive manufacturing is growing in the area of dentistry and orthopedics due to the potential for the fabrication of individual implants. In this...
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Brevilin A inhibits RANKL-induced osteoclast differentiation and bone resorption
Brevilin A (BA) is the primary component of Centipeda minima , which is widely used in Chinese traditional medicine. The anti-inflammatory and...
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Schizophyllan promotes osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro
BackgroundBioactive polysaccharides are a promising way for bone disease prevention with high efficiency. Schizophyllan (SPG) is a polysaccharide...
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Comprehensive ceRNA network for MACF1 regulates osteoblast proliferation
BackgroundPrevious studies have shown that microtubule actin crosslinking factor 1 (MACF1) can regulate osteoblast proliferation and differentiation...
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SDF-1 and NOTCH signaling in myogenic cell differentiation: the role of miRNA10a, 425, and 5100
BackgroundSkeletal muscle regeneration is a complex process regulated by many cytokines and growth factors. Among the important signaling pathways...
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Molecular evolution of transcription factors AF4/FMR2 family member (AFF) gene family and the role of lamprey AFF3 in cell proliferation
AF4/FMR2 family member (AFF) proteins are a group of transcriptional regulators that can regulate gene transcription and play an important role in...
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Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids
Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and...
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Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation
Thioredoxin interacting protein (Txnip) is a stress-responsive factor regulating Trx1 for redox balance and involved in diverse cellular processes...
