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Effect of respiratory tract co-colonizers on initial attachment of Neisseria meningitidis
AbstractRespiratory tract is a complex system comprising of unique microbiota inhabitants. Neisseria meningitidis, Staphylococcus aureus,...
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Fusarium solani PQF9 Isolated from Podocarpus pilgeri Growing in Vietnam as a New Producer of Paclitaxel
Endophytic fungi are known as an alternative promising source of anticancer drug, paclitaxel, however fungi inhabiting in medicinal plant Podocarpus...
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Long noncoding RNA LINC00482 silencing sensitizes non-small cell lung cancer cells to cisplatin by downregulating CLASRP via E2F1
Long noncoding RNA LINC00482 (LINC00482) is dysregulated in non-small cell lung cancer cells (NSCLC). Herein, this research examined the actions and...
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Bioassay-guided isolation of cytotoxic constituents from the flowers of Aquilaria sinensis
Bioassay-guided fractionation of the EtOH extract from the flowers of Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae) led to the isolation of a...
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Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC
BackgroundSolute carrier family 7 member 2 (SLC7A2), a cationic amino acid transporter, is lowly expressed in ovarian and hepatocellular cancers,...
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Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation
Radiation-induced pulmonary fibrosis (RIPF) is a major side effect experienced for patients with thoracic cancers after radiotherapy. RIPF is poor...
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Evaluation of the cytotoxic, anticancer, and genotoxic activities of Acacia nilotica flowers and their effects on N-methyl-N-nitrosourea-induced genotoxicity in mice
PurposeIn this study, two main research objectives were examined: (1) the cytotoxic and anticancer activities of the aqueous methanol extract from Aca...
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Significance of NOTCH1 Expression in the Progression of Human Lung and Colorectal Cancers
AbstractLung and colorectal cancers are the most common types of cancer characterized by a poor prognosis and a high mortality rate. Mutations in the...
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Eleuthemarins A and B, two new isocoumarin derivatives from the Arctic fungus Eleutheromyces sp. CPCC 401592
Two new isocoumarin derivatives, eleuthemarins A ( 1 ) and B ( 2 ), were isolated from the Arctic fungus Eleutheromyces sp. CPCC 401592. Their structures...
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The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data
BackgroundNeoadjuvant chemotherapy (NACT) becomes the first-line option for advanced tumors, while patients who are not sensitive to it may not...
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Novel tetraaza macrocyclic Schiff base complexes of bivalent zinc: microwave-assisted green synthesis, spectroscopic characterization, density functional theory calculations, molecular docking studies, in vitro antimicrobial and anticancer activities
In the present manuscript, novel macrocyclic Schiff base complexes [Zn(N 4 MacL 1 )Cl 2 –Zn(N 4 MacL 3 )Cl 2 ] were synthesized by the reaction of ZnCl 2 and...
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Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition
Nicaraven has been reported to inhibit the activity of poly (ADP-ribose) polymerase (PARP). In this study, we investigated the probable ability of...
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Potential Anticancer Activity of Retrocyclin-3: An in vitro Study
Lung cancer is a prevalent and life-threatening disease that requires potent and selective antitumor agents for effective treatment. Antimicrobial...
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Antineoplastic effects of erufosine on small cell and non-small cell lung cancer cells through induction of apoptosis and cell cycle arrest
BackgroundLung cancer (LC) is the most common types of cancer worldwide and is marked by high mortality rate. LC is classified into two major types...
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Novel pyridinecarboxaldehyde thiosemicarbazone conjugated magnetite nanoparticulates (MNPs) promote apoptosis in human lung cancer A549 cells
The present study highlights the apoptotic activity of magnetic Fe 3 O 4 nanoparticulates functionalized by glutamic acid and 2-pyridinecarboxaldehyde...
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Apoptotic, Cytotoxic and Antimigratory Activities of Phenolic Compounds
AbstractThe objective of this study was to evaluate the biological activities of chrysin (CRY), curcumin (CUR), and ellagic acid (EA) by comparing...
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Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells
BackgroundBone morphogenetic proteins (BMP) are evolutionarily conserved morphogens that are reactivated in lung carcinomas. In lung cancer cells,...
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Synthesis of Some New Coumarin-thiazolidine-2,4-dione-1,2,3-triazole Hybrids as Tubulin Targeting Anti-Lung Cancer Agents
AbstractObjective: Synthesis of some new coumarin-thiazolidine-2,4-dione-1,2,3-triazoles and evaluation of their anti-lung cancer activity. Methods: ...
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NEDD4 Regulated Pyroptosis Occurred from Co-infection between Influenza A Virus and Streptococcus pneumoniae
Co-infection of respiratory tract viruses and bacteria often result in excess mortality, especially pneumonia caused by influenza viruses and Streptoco...
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Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities
Three new nonenes, verrucanonenes A‒C ( 1 ‒ 3 ), were isolated from culture broth of marine-derived fungus Albifimbria verrucaria . These compounds were...
