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Molecular dynamic simulations reveal anti-SARS-CoV-2 activity of mitocurcumin by potentially blocking innate immune evasion proteins NSP3 and NSP16
The coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is affecting human life in an...
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Genetic resilience of Atlantic forest trees to impacts of biome loss and fragmentation
Understanding populational genetic diversity is crucial for making proper decisions about conservation and sustainable species management. In this...
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A comparison of marker-based estimators of inbreeding and inbreeding depression
BackgroundThe availability of genome-wide marker data allows estimation of inbreeding coefficients ( F , the probability of identity-by-descent, IBD)...
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Independent radiation of snailfishes into the hadal zone confirmed by Paraliparis selti sp. nov. (Perciformes: Liparidae) from the Atacama Trench, SE Pacific
Snailfishes are among the most rapidly radiating families of marine fishes, resulting in a global distribution from the coastal intertidal to deep...
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Enzymatic properties of a non-classical aldoxime dehydratase capable of producing alkyl and arylalkyl nitriles
AbstractNitriles are of significant interest in the flavor and fragrance industries with potential application in cosmetics due to their higher...
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Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects
BackgroundOocyte maturation arrest and early embryonic arrest are important reproductive phenotypes resulting in female infertility and cause the...
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Developmental Homology
Homology Homology description is the fundamental determinant of the sameness of biological charactersBiological characters or traits. When two...
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Inbreeding depression in yield-related traits revealed by high-throughput sequencing in hexaploid persimmon breeding populations
Crossbreeding within narrow genetic resources increases the homozygosity of the offspring. Resultant inbreeding depression can reduce the yield...
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A novel approach of kinship determination based on the physical length of genetically shared regions of chromosomes
BackgroundDetermination of genetic relatedness between individuals plays a crucial role in resolving numerous civil cases involving familial...
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Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation
Stimulator of interferon gene (STING) is increasingly exploited for the potential in cancer immunotherapy, yet its mechanism of activation remains...
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Pathway analysis of host responses to dengue virus serotype 2 infection and inhibition of viral envelope protein by naringenin from Ganoderma lucidum
Dengue fever cases are spiking over the last two decades. Incessant efforts are still being made to gain deeper insights on this arboviral disease...
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Genetic evidence for a single founding population of the Lakshadweep Islands
Lakshadweep is an archipelago of 36 islands located in the Southeastern Arabian Sea. In the absence of a detailed archaeological record, the human...
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Hunting the main protease of SARS-CoV-2 by plitidepsin: Molecular docking and temperature-dependent molecular dynamics simulations
COVID-19 has shaken all the countries across the globe and researchers are trying to find promising antiviral to cure the patients suffering from...
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Deciphering the genetic basis of resistance to soybean cyst nematode combining IBD and association map**
Key messageIBD analysis clarified the dynamics of chromosomal recombination during the ZP pedigree breeding process and identified ten genomic...
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Genoty** by sequencing-based linkage map construction and identification of quantitative trait loci for yield-related traits and oil content in Jatropha (Jatropha curcas L.)
BackgroundJatropha ( Jatropha curcas L.) has been considered as a potential bioenergy crop and its genetic improvement is essential for higher seed...
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Personalized genealogical history of UK individuals inferred from biobank-scale IBD segments
BackgroundThe genealogical histories of individuals within populations are of interest to studies aiming both to uncover detailed pedigree...
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Evidence for parent-of-origin effects in autism spectrum disorder: a narrative review
Autism spectrum disorder (ASD) is a heterogeneous group of early-onset neurodevelopmental disorders known to be highly heritable with a complex...
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A Metabarcoding Protocol to Analyze Coastal Planktic Communities Collected by Desalination Plant Filters: From Sampling to Bioinformatic Exploratory Analyses
The temporal dynamics of coastal planktic communities can be disclosed through DNA metabarcoding on the filters of reverse-osmosis desalination...
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A new SSR fingerprinting set and its comparison to existing SSR- and SNP-based genoty** platforms to manage Pyrus germplasm resources
Ensuring the clonal identity of accessions within a germplasm repository, such as the US National Pyrus collection, is critical. Additionally,...
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QTL detection in a pedigreed breeding population of diploid potato
Diploid hybrid potato breeding is emerging as an alternative to breeding tetraploid potato clones. The development of diploid breeding varieties...
