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Neglected bacterial infections associated to bovine respiratory disease in lactating cows from high-yielding dairy cattle herds
Bovine respiratory disease (BRD) is a multifactorial and predominantly multietiological disease that affects dairy cattle herds worldwide, being more...
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Bacterial communities in the gastrointestinal tract segments of helminth-resistant and helminth-susceptible sheep
BackgroundHelminth parasitism is a world-wide problem in livestock industries, with major impacts on health, welfare and productivity. The role of...
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Bacterial and Parasitological Diseases in Laboratory Animals
The laboratory animals harbor a variety of bacterial and parasitic pathogens that cause various diseases. However, many of the pathogens may not...
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Two putative glutamate decarboxylases of Streptococcus pneumoniae as possible antigens for the production of anti-GAD65 antibodies leading to type 1 diabetes mellitus
Type 1 diabetes mellitus (T1DM) has been increasing in prevalence in the last decades and has become a global burden. Autoantibodies against human...
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Identification and evaluation of a panel of strong constitutive promoters in Listeria monocytogenes for improving the expression of foreign antigens
AbstractAttenuated Listeria monocytogenes could be a potential vaccine vector for the immunotherapy of tumors or pathogens. However, the lack of...
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Creation of Multimeric Single-Domain Antibodies Using Bacterial Superglues
Multimerization of single-domain antibodies (sdAbs) is instrumental for construction of antibody molecules with high avidity, extended in vivo...
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Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota
The elucidation of the mechanisms of ageing and the identification of methods to control it have long been anticipated. Recently, two factors...
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Maximum antigen diversification in a lyme bacterial population and evolutionary strategies to overcome pathogen diversity
Natural populations of pathogens and their hosts are engaged in an arms race in which the pathogens diversify to escape host immunity while the hosts...
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Recombinant Antigens E6 and E7 of Human Papilloma Virus Type 16: Preparation, Purification, and Assessment of the Immunogenicity and Antitumor Effects In Vivo
AbstractThe recombinant proteins E6-CBD and E7-CBD, which are antigens E6 and E7 of human papillomavirus type 16 (HPV16), were connected by a...
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Enhancement of Immune Responses Elicited by Nanovaccines through a Cross-Presentation Pathway
Numerous studies have aimed to develop novel advanced vaccines, in part because traditional vaccines have been unsuccessful in preventing rapidly...
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Pathogenesis Mediated by Bacterial Membrane Vesicles
The release of extracellular vesicles (EVs) is a process conserved across the three domains of life. Amongst prokaryotes, EVs produced by...
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Architecture and Assembly of the Bacterial Flagellar Motor Complex
One of the central systems responsible for bacterial motility is the flagellum. The bacterial flagellum is a macromolecular protein complex that is...
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Bacteriophage Virus-Like Particles: Platforms for Vaccine Design
Virus-like particles (VLPs) derived from bacteriophages have many applications in biomedical sciences, especially in the development of candidate...
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Plant Molecular Farming for Vaccine Development
Vaccines are effective tools for the prophylaxis of infectious diseases. Various diseases have been eradicated using vaccines, and the importance of...
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Genomic landscapes of bacterial transposons and their applications in strain improvement
AbstractTransposons are mobile genetic elements that can give rise to gene mutation and genome rearrangement. Due to their mobility, transposons have...
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In Silico Design of a Poly-epitope Vaccine for Urinary Tract Infection Based on Conserved Antigens by Modern Vaccinology
Immunoinformatics or vaccine informatics focuses on applying computational approaches to advance vaccine research and development (R&D). It is also...
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How microbiological tests reflect bacterial pathogenesis and host adaptation
Historically, clinical microbiological laboratories have often relied on isolation of pure cultures and phenotypic testing to identify...
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ssDNA recombineering boosts in vivo evolution of nanobodies displayed on bacterial surfaces
ssDNA recombineering has been exploited to hyperdiversify genomically-encoded nanobodies displayed on the surface of Escherichia coli for originating...
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Methods for Assessment of OMV/GMMA Quality and Stability
Outer membrane vesicles (OMV) represent a promising platform for the development of vaccines against bacterial pathogens. More recently, bacteria...
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