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Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors
Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane...
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Biophysical and Pharmacological Characteristics of Native Two-Pore Domain TASK Channels in Rat Adrenal Glomerulosa Cells
Multiple genes of the TASK subfamily of two-pore domain K + channels are reported to be expressed in rat glomerulosa cells. To determine which TASK...
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Functional Expression of Inward Rectifier Potassium Channels in Cultured Human Pulmonary Smooth Muscle Cells: Evidence for a Major Role of Kir2.4 Subunits
Strong inwardly rectifying K + (K IR ) channels that contribute to maintaining the resting membrane potential are encoded by the Kir2.0 family...
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Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels
The mammalian family of two-pore domain K + (K2P) channel proteins are encoded by 15 KCNK genes and subdivided into six subfamilies on the basis of...
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Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies
There are many mutations in the ryanodine receptor (RyR) Ca 2+ release channel that are implicated in skeletal muscle disorders and cardiac...
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Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?
Apoptosis is a phenomenon fundamental to higher eukaryotes and essential to mechanisms controlling tissue homeostasis. Bcl-2 family proteins tightly...
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Epithelial Sodium Channel in Planar Lipid Bilayers
Amiloride-sensitive Na+ channels belong to the epithelial Na+ channel (ENaC)-degenerin superfamily of ion channels. In addition to their key role in...
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Studying the Mechanosensitivity of Voltage-Gated Channels Using Oocyte Patches
The mechanosensitivity of voltage-gated (VG) channels is of biophysical, physiological, and pathophysiological interest. Xenopus oocytes offer a...
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Protein Aggregation, Ion Channel Formation, and Membrane Damage
A plethora of clinical syndromes are characterized by the deposition of amorphous, Congo red staining material known as “amyloid.” These protein...
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A Role for the 2′ Residue in the Second Transmembrane Helix of the GABAA Receptor γ2S Subunit in Channel Conductance and Gating
GABA A receptors composed of α, β and γ subunits display a significantly higher single-channel conductance than receptors comprised of only α and β...
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Sodium-dependent Potassium Channels in Leech P Neurons
In leech P neurons the inhibition of the Na + -K + pump by ouabain or omission of bath K + leaves the membrane potential unaffected for a prolonged...
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Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6
The immunophilin, FK506-binding protein (FKBP12), is an essential component of the ryanodine receptor channel complex of skeletal muscle (RyR1) and...
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Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli
Apoptotic cell death is an essential process in the development of the central nervous system and in the pathogenesis of its degenerative diseases....
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The voltage-dependent anion channel-1 modulates apoptotic cell death
The role of the voltage-dependent anion channel (VDAC) in cell death was investigated using the expression of native and mutated murine VDAC1 in...
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Amyloid Peptide Channels
At least 16 distinct clinical syndromes including Alzheimer’s disease (AD), Parkinson’s disease (PD), rheumatoid arthritis, type II diabetes mellitus...
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Distributions-per-Level: A Means of Testing Level Detectors and Models of Patch-Clamp Data
Level or jump detectors generate the reconstructed time series from a noisy record of patch-clamp current. The reconstructed time series is used to...
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Membrane topology and membrane retention of the ryanodine receptor calcium release channel
The ryanodine receptor (RyR) is a Ca 2+ release channel located in the sarcoplasmic/endoplasmic reticulum (ER) membrane and plays a critical role in...
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Effects of Chronic Hypoxia on Inward Rectifier K + Current (I K1) in Ventricular Myocytes of Crucian Carp (Carassius carassius) Heart
Some ectothermic vertebrates show unusually good tolerance to oxygen shortage and it is therefore assumed that they might, as a defense mechanism,...
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17b-Estradiol and Tamoxifen Regulate a Maxi-Chloride Channel from Human Placenta
Steroid hormones have been implicated in the modulation of several transport processes, including conductive chloride transport in epithelial cells....