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Salt Stress Tolerance and Calcium Signalling Components: Where We Stand and How Far We can Go?
Soil salinization emerges as a pervasive global challenge, impeding plant growth and exerting substantial constraints on agricultural development and...
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GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation
γ-Aminobutyrate (GAB), the biochemical form of (GABA) γ-aminobutyric acid, participates in sha** physiological processes, including the immune...
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Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways
Phenotypic and functional changes in vascular smooth muscle cells (VSMCs) contribute significantly to cardiovascular diseases (CVD) but factors...
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A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis
How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryonal tumour, remains...
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CDPKs Based Signalling Network: Protecting the Wheat from Heat
Wheat, being a staple food grain crop, is highly sensitive to terminal heat stress. The mechanism underlying heat stress tolerance in wheat has yet...
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Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling
Intestinal stem cells (ISCs) play a crucial role in the continuous self-renewal and recovery of the intestinal epithelium. In previous studies, we...
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DADS Inhibits the Proliferation of MDCC-MSB-1 Cells by Inducing Autophagy via the MEK/ERK Signalling Pathway
AbstractDiallyl disulfide (DADS) is effective at suppressing tumour cell growth and proliferation. This study verified the morphology and growth...
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Heavy Metal Stress–Induced Activation of Mitogen-Activated Protein Kinase Signalling Cascade in Plants
In recent years, as a result of anthropogenic activities, a rise in environmental stresses has been observed. Sessile organisms such as plants make...
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Direct attenuation of Arabidopsis ERECTA signalling by a pair of U-box E3 ligases
Plants sense a myriad of signals through cell-surface receptors to coordinate their development and environmental response. The Arabidopsis ERECTA...
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GALNT14 in association with GDF-15 promotes stemness and drug resistance through β-catenin signalling pathway in breast cancer
BackgroundAltered glycosylation plays a role in carcinogenesis. GALNT14 promotes cancer stem-like properties and drug resistance. GDF-15 is known to...
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Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4
To date, there is no effective therapy for pathological cardiac hypertrophy, which can ultimately lead to heart failure. Bellidifolin (BEL) is an...
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ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Heart failure is a major cause of morbidity and mortality worldwide, and can result from pressure overload, where cardiac remodelling is...
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The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signalling
Colorectal cancer (CRC) is the second leading cause of cancer deaths. Though chemotherapy is the main treatment option for advanced CRC, patients...
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Role of pH in the Control of Fungal MAPK Signalling and Pathogenicity
Like all organisms, fungi have evolved sophisticated mechanisms for ambient pH sensing and adaptation, as well as an exquisitely tuned system for...
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Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling
Acute myeloid leukaemia (AML) is a haematological malignancy characterised by the accumulation of transformed myeloid progenitors in the bone marrow....
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Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice
While pancreatic β and α cells are considered the main drivers of blood glucose homeostasis through insulin and glucagon secretion, the contribution...
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Sensing and Signalling in Diatom Responses to Abiotic Cues
Diatoms are prominent microalgae that proliferate in a wide range of aquatic environments. Still, fundamental questions regarding their biology, such...
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Horizontal transfer of miR-383 sensitise cells to cisplatin by targeting VEGFA-Akt signalling loop
BackgroundCellular resistance to cisplatin has been one of the major obstacles in the success of combination therapy for many types of cancers....
