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Traditional and Non-traditional Risk Factors for Osteoporosis in CKD
Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of...
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Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics
In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an increase in interest in alternate therapies. Peptide-based...
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Congenital Conditions of Hypophosphatemia Expressed in Adults
The main congenital conditions of hypophosphatemia expressed in adulthood include several forms of hereditary hypophosphatemic rickets and a...
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Novel mutation in LRP5 gene cause rare osteosclerosis: cases studies and literature review
To study the effects of low-density lipoprotein receptor-related protein 5 ( LRP5 ) gene mutations on bone, and to open up our view of LRP5 and Wnt...
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IL-17A inhibits the degradation of RANKL in osteoblasts by inhibiting BCL2-Beclin1-autophagy signaling
The inflammatory cytokine IL-17A is known to have the capacity to promote osteoclastogenesis, thereby enhancing bone loss. Moreover, IL-17A can...
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Parathyroid Cell Differentiation from Progenitor Cells and Stem Cells: Development, Molecular Mechanism, Function, and Tissue Engineering
Parathyroid glands are endocrine organs which are located posterior to thyroid glands and control secretion of parathyroid hormone (PTH) in order to...
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Role of Phosphate in Biomineralization
Inorganic phosphate is a vital constituent of cells and cell membranes, body fluids, and hard tissues. It is a major intracellular divalent anion,...
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Radiopharmaceuticals for Non-Glucose-Specific Oncology (PET and SPECT) (A Review)
AbstractTo date, the most common drug for diagnosis of cancer tumors is [ 18 F]-fluorodeoxyglucose, a radiopharmaceutical for positron emission...
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Tumor-Induced Osteomalacia
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumoral production of fibroblast growth factor 23 (FGF23). The hallmark...
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Referral rate, profile and degree of control of patients with familial hypercholesterolemia: data from a single lipid unit from a Mediterranean area
BackgroundThe challenging rigorous management of hypercholesterolemia promotes referral to specialized units. This study explored the need, based on...
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Associations Between Aldosterone-Renin-Ratio and Bone Parameters Derived from Peripheral Quantitative Computed Tomography and Impact Microindentation in Men
Components of the renin–angiotensin–aldosterone system (RAAS) are present on bone cells. One measure of RAAS activity, the aldosterone-renin-ratio...
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Inflammatory Arthritis
The spectrum of disease manifestations for a given disease is highly specific and reproducible across phylogenetic lines. Examined on a population...
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Bone Fragility Fractures in CKD Patients
Chronic kidney diseases (CKD) are associated with mineral and bone diseases (MBD), including pain, bone loss, and fractures. Bone fragility related...
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Determinants of Low Bone Turnover in Type 2 Diabetes-the Role of PTH
Determinants of low bone turnover in type 2 diabetes (T2DM) are poorly understood. To investigate the relationship between markers of bone turnover,...
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New Therapies for Hypophosphatemia-Related to FGF23 Excess
FGF23 is a hormone produced by osteocytes in response to an elevation in the concentration of extracellular phosphate. Excess production of FGF23 by...
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Inflammation, Oxidative Stress, and Bone in Chronic Kidney Disease in the Osteoimmunology Era
Bone is not only a mineralized and apparently non-vital structure that provides support for locomotion and protection to inner organs. An increasing...
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Insights from Proteomics in Kidney Disease Diagnosis and Various In Vitro and In Vivo Experimental Models
Kidney disease is emerging as a significant cause of mortality and public health burden worldwide. Diabetes, hypertension, obesity, and drug toxicity...
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Diagnosis of canine spontaneous hypoadrenocorticism
Hypoadrenocorticism is characterized by a reduction in mineralocorticoid and/or glucocorticoid production by the adrenal glands. Several subtypes...
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Are Serum 25-Hydroxyvitamin D Deficiency and Insufficiency Risk Factors for the Incidence of Dynapenia?
Epidemiological evidence showing the association between low 25(OH)D and age-related reduction in neuromuscular strength (dynapenia) is a paucity and...
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Dapagliflozin and Liraglutide Therapies Rapidly Enhanced Bone Material Properties and Matrix Biomechanics at Bone Formation Site in a Type 2 Diabetic Mouse Model
The aim of this study is to compare head-to-head the effects of dapagliflozin and liraglutide on bone strength and bone material properties in a...
