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Results of Targeted Sequencing of PRL, PRLR, and PRLHR Genes in Young Women with Nonneoplastic Hyperprolactinemia
AbstractThe goal of the study was exploring the range of variants of the PRL , PRLR , and PRLHR genes in women of reproductive age with nontumor...
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Effect of Probiotics on Gut Microbiota and Brain Interactions in the Context of Neurodegenerative and Neurodevelopmental Disorders
The bidirectional communication between the gut and the brain links emotional and cognitive centers of the brain with peripheral intestinal...
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Biosafety Assessment of Synthetic Pesticides
Pesticides are poisonous substances with particular modes of action (MoAs) that are intended to destroy living things. The number of pesticides on...
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Effects of Semax in the Rat Models of Acute Stress
AbstractAcute stress exposure triggers a cascade of neurochemical reactions, leading, specifically, to behavior changes and increased pain tolerance...
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The left–right side-specific endocrine signaling in the effects of brain lesions: questioning of the neurological dogma
Each cerebral hemisphere is functionally connected to the contralateral side of the body through the decussating neural tracts. The crossed neural...
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A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior
BackgroundAn essential determinant of a neuron’s functionality is its neurotransmitter phenotype. We previously identified a defined subpopulation of...
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Evolution of Peptide Drug Biopharmaceutics
Abstract—Peptides are low-molecular-weight substances involved in numerous physiological processes, such as growth and development of the organism,...
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What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals
All animals evolved from a single lineage of unicellular precursors more than 600 million years ago. Thus, the biological and genetic foundations for...
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Intermittent Restraint Stress and Recovery on GPCR Expression in Brain/Gut Axis of Mice: Activation of Adrenergic, Dopamine, Serotonin and Melatonin Receptors During Stress and Ease Response
G protein-coupled receptors (GPCRs) comprise the largest family of integral membrane proteins that regulate many important physiological functions....
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Integration of photoperiodic and temperature cues by the circadian clock to regulate insect seasonal adaptations
Organisms adapt to unfavorable seasonal conditions to survive. These seasonal adaptations rely on the correct interpretation of environmental cues...
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Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling
BackgroundOxytocin, secreted by oxytocin neurons in the hypothalamus, is an endogenous neuropeptide involved in modulating multiple sensory...
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POMC neuronal heterogeneity in energy balance and beyond: an integrated view
Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of the body’s energy status, since they act in an opposite manner to...
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Origin and Evolution of the Nervous System: New Data from Comparative Whole Genome Studies of Multicellular Animals
AbstractFor evolutionary neuroscience, 2021 is associated with great research achievements based on cell whole genome sequencing methods. These...
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Shining a Light on Trace Elements: A Systematic Review and Meta-analysis of Serum Concentrations in Febrile seizure
Febrile seizures (FS) are a common occurrence in pediatric patients and are typically triggered by high fevers above 100.4°F (38°C), often associated...
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Differentiated Approach to Pharmacotherapy of Autism Spectrum Disorders: Biochemical Aspects
AbstractAutism Spectrum Disorders (ASD) are highly heterogeneous neurodevelopmental disorders caused by a complex interaction of numerous genetic and...
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Bifidobacteria in disease: from head to toe
Bifidobacteria as a strictly anaerobic gram-positive bacteria, is widely distributed in the intestine, vagina and oral cavity, and is one of the...
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Gut–Brain Axis: Role of the Gut Microbiome on Human Health
The gut microbiome is considered as an organ that contributes to the regulation of host metabolism. Mammals possess an ‘extended genome’ of millions...
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On the origin and evolution of the dual oscillator model underlying the photoperiodic clockwork in the suprachiasmatic nucleus
Decades have now passed since Colin Pittendrigh first proposed a model of a circadian clock composed of two coupled oscillators, individually...
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Sea cucumbers: an emerging system in evo-devo
A challenge for evolutionary developmental (evo-devo) biology is to expand the breadth of research organisms used to investigate how animal diversity...
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Role of Lipids in Regulation of Neuroglial Interactions
AbstractLipids comprise an extremely heterogeneous group of compounds that perform a wide variety of biological functions. Traditional view of lipids...
