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Short telomeres impede germ cell specification by upregulating MAPK and TGFβ signaling
Functional telomeres protect chromosome ends and play important roles in stem cell maintenance and differentiation. Short telomeres negatively impact...
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Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC/PKC/MAPK pathway
BackgroundThe regeneration of bone loss that occurs after periodontal diseases is a significant challenge in clinical dentistry. Extracellular...
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PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway
Some studies have reported that activated ribosomes are positively associated with malignant tumors, especially in hepatocellular carcinoma (HCC)....
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p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
BackgroundChronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation due to airway...
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Targeting ARNT attenuates chemoresistance through destabilizing p38α-MAPK signaling in glioblastoma
Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. This study aimed to investigate the functional significance of aryl...
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PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation
BackgroundPreviously, we identified an oncogenic splicing variant of DOCK5 in head and neck squamous cell carcinoma (HNSCC); however, the mechanism...
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p38-MAPK is prerequisite for the synthesis of SARS-CoV-2 protein
The inhibition of p38 mitogen-activated protein kinase (p38-MAPK) by small molecule chemical inhibitors was previously shown to impair severe acute...
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MiR-214 inhibits apoptosis in thyroid epithelial follicular cells induced by amiodarone through the FASL/MAPK pathway
BackgroundHashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is one of the most common autoimmune disease (AITD) in...
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Role of pH in the Control of Fungal MAPK Signalling and Pathogenicity
Like all organisms, fungi have evolved sophisticated mechanisms for ambient pH sensing and adaptation, as well as an exquisitely tuned system for...
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Lipid metabolism and MAPK-ICE1 cascade play crucial roles in cold tolerance of banana
Low temperature is a major environmental factor that limits the growth, yield, and geographical distribution of Cavendish and Dajiao bananas ( Musa ...
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C-type natriuretic peptide promotes adipogenic differentiation of goat adipose–derived stem cells via cGMP/PKG/ p38 MAPK signal pathway
C-type natriuretic peptide (CNP) is a member of natriuretic peptide family, which plays unique roles in cardiovascular system. Once CNP binds to...
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Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway
The study aimed to investigate the potential role of lysine-specific demethylase 5A (KDM5A) in cisplatin-induced ototoxicity. The effect of the KDM5A...
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Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway
The type I cGMP-dependent protein kinase (PKG I) is recognized as a tumor suppressor, but its role in EGFR regulated epithelial ovarian cancer (EOC)...
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Retinoprotective Effect of SkQ1, Visomitin Eye Drops, Is Associated with Suppression of P38 MAPK and ERK1/2 Signaling Pathways Activity
AbstractVisomitin eye drops are the first and, so far, the only drug based on SkQ1 – the mitochondria-targeted antioxidant 10-(6′-plastoquinonyl)...
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Natural astaxanthin enhanced antioxidant capacity and improved semen quality through the MAPK/Nrf2 pathway in aging layer breeder roosters
BackgroundNatural astaxanthin (ASTA) has strong antioxidant properties and has been widely used as a health product to improve human health. However,...
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Inhibition of p38 MAPK or immunoproteasome overcomes resistance of chronic lymphocytic leukemia cells to Bcl-2 antagonist venetoclax
Chronic lymphocytic leukemia (CLL) is a hematological neoplasm of CD19-positive mature-appearing B lymphocytes. Despite the clinical success of...
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CD14 Involvement in Third-degree Skin Burn-induced Myocardial Injury via the MAPK Signaling Pathway
This study investigated the potential genes and related pathways in burn-induced myocardial injury. Rat myocardial injury induced by third-degree...
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Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway
Colorectal cancer (CRC) is one of the most common human malignancies in the digestive tract with high mortality. Alantolactone (ATL), as a...
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Inhibitory effect of berberine hydrochloride against Candida albicans and the role of the HOG-MAPK pathway
Berberine hydrochloride (BH), an active component of Coptis chinensis and other plant taxa, has broad antimicrobial activity and may be useful for...
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Identification and analysis of MAPK cascade gene families of Camellia oleifera and their roles in response to cold stress
BackgroundLow-temperature severely limits the growth and development of Camellia oleifera ( C. oleifera ). The mitogen-activated protein kinase (MAPK)...
