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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles...
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Oxidative stress signalling
Oxidative stress arises from an imbalance in the generation and removal of reactive oxygen species (ROS) within cells. ROS are produced during...
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Stress-induced brain responses are associated with BMI in women
Overweight and obesity are associated with altered stress reactivity and increased inflammation. However, it is not known whether stress-induced...
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Acute Aluminum Sulfate Triggers Inflammation and Oxidative Stress, Inducing Tissue Damage in the Kidney of the Chick
In this study, a total of 20 7-day-old chicks were randomly divided into an experimental group and a control group. The experimental group was...
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Hepatic Sirt6 activation abrogates acute liver failure
Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the...
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Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes
The mechanisms leading to changes in mesoscale chromatin organization during cellular aging are unknown. Here, we used transcriptional activator-like...
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MicroRNA Biogenesis in Cell Senescence Induced by Chronic Endoplasmic Reticulum Stress
AbstractMicroRNAs are small noncoding RNAs that regulate gene expression; stabilize the cell phenotype; and play an important role in cell...
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Early stress exposure on zebrafish development: effects on survival, malformations and molecular alterations
The effects of stress during early vertebrate development can be especially harmful. Avoiding stressors in fish larvae is essential to ensure the...
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GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response
Sepsis is a serious clinical condition characterized by a systemic inflammatory response, a leading cause of acute liver and kidney injury, and is...
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Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington’s disease
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat in the Huntingtin ( HTT ) gene, encoding a...
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Immune, Inflammatory and Oxidative Stress-Related Biomarkers
In the exploration of schizophrenia spectrum disorders (SSD) pathophysiology, the involvement of inflammatory processes, mitochondrial functions, and...
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Ozone Stress
Atmospheric ozone (O3) is present both in stratosphereStratosphere and troposphereTroposphere. It has both beneficial (photo-protectant) role and...
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Inferring the genetic responses to acute drought stress across an ecological gradient
BackgroundHow do xerophytic species thrive in environments that experience extreme annual drought? Although critical to the survival of many species,...
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Physical Stress Attenuates Cognitive Inhibition: An fNIRS Examination
This study aimed to assess the haemodynamics in the prefrontal cortex (PFC) and salivary α-amylase (sAA) response during acute physical stress. Acute...
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Effects of acute heat stress on haemato-biochemical parameters, oxidative resistance ability, and immune responses of hybrid yellow catfish (pelteobagrus fulvidraco × P. vachelli) juveniles
This study investigated the effect of heat stress on the physiological parameters, oxidation resistance ability and immune responses in juvenile...
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Switch from fight-flight to freeze-hide: The impacts of severe stress and brain serotonin on behavioral adaptations in flatfish
Animals often experience changes in their environment that can be perceived as stressful. Previous evidence indicates that different individuals may...
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Stress-responsive Gdf15 counteracts renointestinal toxicity via autophagic and microbiota reprogramming
The integrated stress response (ISR) plays a pivotal role in the cellular stress response, primarily through global translational arrest and the...
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Acute hypoxia causes glycolysis and lipid metabolism alterations with HSPs’ persistent activation in Leiocassis longirostris
Hypoxia is one of the common stress factors encountered in intensive farming. Leiocassis longirostris is a commercially valuable fish with limited...
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Modulation of the innate immune response, antioxidant system and oxidative stress during acute and chronic stress in pacu (Piaractus mesopotamicus)
Stress is an energy-demanding process, as well as the responses of the innate immune system, that impose a metabolic overload on cellular energy...
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Signaling Pathways in Plant Responses to Abiotic Stress
Recent scientific advancements have significantly improved our understanding of plant signaling pathways under abiotic stress. However, further...