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Initial stages of DNA Base Excision Repair in Nucleosomes
AbstractIn mammalian cells, base excision repair (BER) is the main pathway responsible for the correction of a variety of chemically modified DNA...
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Transcription of DNA-Methyltransferases in Endothelial Cells Exposed to Mitomycin C
AbstractDNA-methyltransferases catalyze DNA methylation in the CpG sites, which play an important role in the maintenance of genome stability. The...
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Investigation of XPD, miR-145 and miR-770 expression in patients with end-stage renal disease
BackgroundThe effective maintenance of genome integrity and fidelity is vital for the normal function of our tissues and organs, and the prevention...
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Methylation Status of Arabidopsis DNA Repair Gene Promoters During Agrobacterium Infection Reveals Epigenetic Changes in Three Generations
Agrobacterium tumefaciens is a unique pathogen with the ability to transfer a portion of its DNA, the T-DNA, to other organisms. The role of DNA...
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Generation of Recombinant Nucleosomes Containing Site-Specific DNA Damage
Eukaryotic DNA exists in chromatin, where the genomic DNA is packaged into a fundamental repeating unit known as the nucleosome. In this chromatin...
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The Role of the WGR Domain in the Functions of PARP1 and PARP2
AbstractThe PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication,...
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Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway
Telomere erosion and mitochondrial dysfunction are prominent features of aging cells with progressive declines of cellular functions. Whether...
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Exon Sequence Analysis of the ATG5, ATG12, ATG9B Genes in Colorectal Cancer Patients During Radiotherapy
Radiotherapy (RT) which is a treatment regime for cancer patients may cause genetic instability and side effects. Etiological associations exist...
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Circ_0000277 promotes the malignant progression of oesophageal squamous cell carcinoma through miR-1294-dependent regulation of DVL3
BackgroundRecent studies have pinpointed that circular RNA (circRNA) regulates diverse cellular processes in oesophageal squamous cell carcinoma...
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DNA Mutation, Repair, and Recombination
A mutation is a process of alteration in genome sequence by mistakes during DNA replication or as the result of environmental stress including...
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In Silico Analysis and Comparison of Pathogenesis-related Transcription Factor Binding Sites in Arabidopsis DNA Repair Gene Promoters
Pathogens alter defense gene responses, genome stability, and DNA repair machinery of plants. The regulation of defense gene expression relies much...
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The landscape of chromatin accessibility in skeletal muscle during embryonic development in pigs
BackgroundThe development of skeletal muscle in pigs during the embryonic stage is precisely regulated by transcriptional mechanisms, which depend on...
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Functional Diversity of SIRT7 Across Cellular Compartments: Insights and Perspectives
Posttranslational modifications (PTMs) play important roles in the regulation of protein function. Acetylation and deacetylation are among the most...
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Loss of the receptors ER, PR and HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer
Poly(ADP-ribose) polymerase 1 (PARP1) is essential for the progression of several types of cancers. However, whether and how PARP1 is stabilized to...
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The Application of Electromagnetic Fields in Cancer
The use of nonionizing electromagnetic fields (EMFs) has attracted interest in cancer research during the past few decades due to its noninvasive...
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Genetic Variant Arg399Gln G>A of XRCC1 DNA Repair Gene Enhanced Cancer Risk Among Indian Population: Evidence from Meta-analysis and Trial Sequence Analyses
The X-ray repair cross-complementation group 1 ( XRCC1 ) gene plays an important role in base excision repair pathway. Several studies have reported...
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Meta-analysis of polymorphic variants conferring acute lymphoblastic leukemia risk in the Indian population
AbstractAcute lymphoblastic leukemia (ALL) is a rapidly progressive bone marrow cancer in which early lymphoid precursors proliferate and replace the...
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Deciphering the Role of Exosomal Non-Coding RNA (ncRNA) in Drug Resistance of Gastrointestinal Tumors; an Updated Review
One of the most prevalent types of cancer worldwide today is gastric intestinal (GI) tumors. To guarantee their lives, people with a developed GI...
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The Choice of a Donor Molecule in Genome Editing Experiments in Animal Cells
Abstract—Genome editing is a powerful tool that allows study of the properties of genes or changes to be made to the genetic sequence. Programmable...
