Search
Search Results
-
Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC)
The combination of immune checkpoint inhibitors (ICIs) with chemotherapy (chemoimmunotherapy) in the neoadjuvant setting have achieved favorable...
-
BD Rhapsody™ Single-Cell Analysis System Workflow: From Sample to Multimodal Single-Cell Sequencing Data
Advancements in single-cell sequencing have revolutionized our understanding of complex biological systems such as the immune system and allowed us...
-
-
Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge
BackgroundXenobiotics are primarily metabolized by hepatocytes in the liver, and primary human hepatocytes are the gold standard model for the...
-
Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas
Small bowel adenocarcinomas (SBAs) are rare malignant tumors with a high mortality rate, and their molecular characteristics are still largely...
-
Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
Immunoglobulins (Ig), which exist either as B-cell receptors (BCR) on the surface of B cells or as antibodies when secreted, play a key role in the...
-
-
Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that...
-
Single Cell RNA-Sequencing in Arabidopsis Root Tissues
Droplet-based single-cell RNA-sequencing (scRNA-seq)Single-cell RNA-sequencing (scRNA-seq) empowers transcriptomicTranscriptomics profiling with an...
-
Single-Cell Transcriptomic Analysis of Mononuclear Cell Populations in Skeletal Muscle
Skeletal muscle possesses a remarkable regenerative capacity, mainly relying on a population of undifferentiated and unipotent muscle progenitors,...
-
Profiling epigenetic age in single cells
DNA methylation dynamics have emerged as a promising biomarker of mammalian aging, with multivariate machine learning models (‘epigenetic clocks’)...
-
Inferring single-cell copy number profiles through cross-cell segmentation of read counts
BackgroundCopy number alteration (CNA) is one of the major genomic variations that frequently occur in cancers, and accurate inference of CNAs is...
-
Single cell RNA-seq: a novel tool to unravel virus-host interplay
Over the last decade, single cell RNA sequencing (scRNA-seq) technology has caught the momentum of being a vital revolutionary tool to unfold...
-
Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC
Multimodal measurements of single-cell profiles are proving increasingly useful for characterizing cell states and regulatory mechanisms. In the...
-
Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma
An immunosuppressive microenvironment enriched with regulatory CD4 + T lymphocytes (Tregs) facilitates the progression of lung adenocarcinoma (LUAD)....
-
Protoplast Isolation for Plant Single-Cell RNA-seq
The growth and development of plants depends on diversified gene expression in different cell types. Compared to traditional bulk RNA sequencing,...
-
Simultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor choice
The simultaneous measurement of three-dimensional (3D) genome structure and gene expression of individual cells is critical for understanding a...
-
High-throughput single-cell transcriptomics of bacteria using combinatorial barcoding
Microbial split-pool ligation transcriptomics (microSPLiT) is a high-throughput single-cell RNA sequencing method for bacteria. With four...
-
Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH
Methods to spatially profile the transcriptome are dominated by a trade-off between resolution and throughput. Here we develop a method named...
