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Autophagy: a molecular switch to regulate adipogenesis and lipolysis
Obesity is a complex epidemic disease caused by an imbalance of adipose tissue function that results in hyperglycemia, hyperlipidemia and insulin...
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The Effect of Oxidative Stress and Antioxidants Treatment on Gestational Diabetes Mellitus Outcome: A Sco** Review
Diagnosing a pregnant woman’s glucose intolerance is referred to as gestational diabetes mellitus (GDM). Diabetes has been linked to enhanced...
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Brain nuclear receptors and cardiovascular function
Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence...
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The Association Between Blood Mercury and Lipid Biomarkers in US Hypertensive Adults
AbstractMercury (Hg) is detrimental to human health, but its impact on lipid biomarkers remains a subject of controversy. This study sought to...
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Small extracellular vesicle-mediated metabolic reprogramming: from tumors to pre-metastatic niche formation
Metastasis, the spread of a tumor or cancer from the primary site of the body to a secondary site, is a multi-step process in cancer progression,...
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Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease
A computational platform, Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it...
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Exercise and Nutrition: Metabolic Partners in Epigenetic Regulation
Metabolism fuels epigenetic processes, which, in turn, regulate metabolism by translating environmental stimuli into adaptations. Metabolic networks...
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Characterizing influence of rCHOP treatment on diffuse large B-cell lymphoma microenvironment through in vitro microfluidic spheroid model
For over two decades, Rituximab and CHOP combination treatment (rCHOP) has remained the standard treatment approach for diffuse large B-cell lymphoma...
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The inhibitory effects of live and UV-killed Akkermansia muciniphila and its derivatives on cytotoxicity and inflammatory response induced by Clostridioides difficile RT001 in vitro
Clostridioides difficile infection (CDI) is the leading cause of healthcare-acquired infections worldwide. Probiotics are widely recommended to...
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Need for Methods to Investigate Endocannabinoid Signaling
Endocannabinoids (eCBs) are endogenous lipids able to bind to cannabinoid receptors, the primary molecular targets of the cannabis (Cannabis sativa)...
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Metabolite signaling in the heart
The heart is the most metabolically active organ in the body, sustaining a continuous and high flux of nutrient catabolism via oxidative...
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Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway
BackgroundThyroid hormones (THs) regulate growth, development and function of different tissues. Hypothyroidism is a common clinical disorder...
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The role and regulation of SIRT1 in pulmonary fibrosis
Pulmonary fibrosis (PF) is a progressive and fatal lung disease with high incidence and a lack of effective treatment, which is a severe public...
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Physiological, metabolomic, and transcriptomic reveal metabolic pathway alterations in Gymnocypris przewalskii due to cold exposure
Teleost fish have evolved various adaptations that allow them to tolerate cold water conditions. However, the underlying mechanism of this adaptation...
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Lipid metabolism-related genes are involved in the occurrence of asthma and regulate the immune microenvironment
BackgroundLipid metabolism plays a pivotal role in asthma pathogenesis. However, a comprehensive analysis of the importance of lipid...
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Prenatal caloric restriction adjusts the energy homeostasis and behavior in response to acute and chronic variations in food availability in adulthood
Fetal metabolic programming produced by unfavorable prenatal nutritional conditions leads to the development of a disorder called “thrifty...
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Futile lipid cycling: from biochemistry to physiology
In the healthy state, the fat stored in our body isn’t just inert. Rather, it is dynamically mobilized to maintain an adequate concentration of fatty...
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The effect of adiponectin and its receptors in placental development of diabetic rats
Placenta development is an essential process for normal fetal growth and development, and healthy pregnancy maintenance. Inadequate placental...
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RNA-seq analysis of phagocytic cells from murine epididymal white adipose tissue shows immunosenescence and age-related phosphorus metabolism
The underlying state of alterations in adipose tissue is hypothesized to be as a result of age-related changes. Young and aged mice have been...
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Myofiber directs macrophages IL-10-Vav1-Rac1 efferocytosis pathway in inflamed muscle following CTX myoinjury by activating the intrinsic TGF-β signaling
BackgroundTo explore the role of skeletal muscle specific TGF-β signaling on macrophages efferocytosis in inflamed muscle caused by Cardiotoxin (CTX)...
