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Dissecting thrombus-directed chemotaxis and random movement in neutrophil near-thrombus motion in flow chambers
BackgroundThromboinflammation is caused by mutual activation of platelets and neutrophils. The site of thromboinflammation is determined by...
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Chemerin attracts neutrophil reverse migration by interacting with C–C motif chemokine receptor-like 2
Neutrophil reverse migration (rM) is a recently identified phenomenon in which neutrophils migrate away from the inflammatory site back into the...
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The regulatory roles of neutrophils in adaptive immunity
AbstractNeutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence...
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Analysis of Neutrophil Morphology and Function Under Genetic Perturbation of Transcription Factors In Vitro
Hoxb8 cells are immortalized myeloid progenitors that maintain their multipotent potential and can be differentiated into neutrophils. Genetic...
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Detection of Neutrophils in the Sciatic Nerve Following Peripheral Nerve Injury
Injury to the sciatic nerve leads to degeneration and debris clearance in the area distal to the injury site, a process known as Wallerian...
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Game of neutrophils: modeling the balance between apoptosis and necrosis
BackgroundNeutrophils are one of the key players in the human innate immune system (HIIS). In the event of an insult where the body is exposed to...
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Neutrophil diversity is associated with T-cell immunity and clinical relevance in patients with thyroid cancer
Neutrophil heterogeneity is involved in autoimmune diseases, sepsis, and several cancers. However, the link between neutrophil heterogeneity and...
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Gary M. Bokoch, the Rac-n-Rho Man: His Fascination with Rho-GTPases
Dr. Gary Bokoch’s legacy (Fig. 8.1) continues in each of us who learned about RhoGTPases through his training, publications, collaborations, and...
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Cellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion
BackgroundDiabetic retinopathy (DR) is a major cause of blindness and is characterized by dysfunction of the retinal microvasculature. Neutrophil...
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Neutrophil extracellular traps formation: effect of Leishmania major promastigotes and salivary gland homogenates of Phlebotomus papatasi in human neutrophil culture
BackgroundLeishmaniasis as a neglected tropical disease (NTD) is caused by the inoculation of Leishmania parasites via the bite of phlebotomine sand...
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Knockout of the C3a receptor protects against renal ischemia reperfusion injury by reduction of NETs formation
Renal ischemia/reperfusion (I/R) injury is a local sterile inflammatory response driven by innate immunity. Emerging data have revealed that...
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NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain
BackgroundNeutrophil extracellular trap (NET) has been implicated in the pathology of multiple sclerosis (MS) and experimental autoimmune...
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Quantitative Monitoring of GPCR-Mediated Spatiotemporal IP3 Dynamics Using Confocal Fluorescence Microscopy
Activation of G protein-coupled receptors upon chemoattractant stimulation induces activation of multiple signaling pathways. To fully understand how...
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Low-dose ethanol consumption inhibits neutrophil extracellular traps formation to alleviate rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Ethanol consumption has been reported to reduce morbidity in RA patients, but the...
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Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice
In sub-Saharan Africa, multidrug-resistant non-typhoidal Salmonella serovars are a common cause of fatal bloodstream infection. Malnutrition is a...
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Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation
Neutrophils play a crucial role in the immune system within tumor microenvironment. At present, numerous studies have explored the changes of...
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Neutrophil (dys)function due to altered immuno-metabolic axis in type 2 diabetes: implications in combating infections
Metabolic and inflammatory pathways are highly interdependent, and both systems are dysregulated in Type 2 diabetes (T2D). T2D is associated with...
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Peripheral Blood Cell Composition of Baikal Seal Phoca sibirica
AbstractThe cellular composition of the peripheral blood of the Baikal seal Phoca sibirica (Gmelin, 1788) has been studied. Various cells have been...
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Involvement of Mitogen-Activated Protein Kinases p38 and ERK1/2, as well as Protein Kinase B Akt1/2, in the Formation of Neutrophil Extracellular Traps
AbstractNeutrophils release decondensed nuclear chromatin or neutrophil extracellular trap (NETs) in response to a large number of different...
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Non-invasive map** of systemic neutrophil dynamics upon cardiovascular injury
Neutrophils play a complex role during onset of tissue injury and subsequent resolution and healing. To assess neutrophil dynamics upon...
