Search
Search Results
-
RGA1 regulates grain size, rice quality and seed germination in the small and round grain mutant srg5
BackgroundGenerating elite rice varieties with high yield and superior quality is the main goal of rice breeding programs. Key agronomic traits,...
-
Multiomics comparative analysis of the maize large grain mutant tc19 identified pathways related to kernel development
BackgroundThe mechanism of grain development in elite maize breeding lines has not been fully elucidated. Grain length, grain width and grain weight...
-
Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study
In this work, we designed new terpenoid-peptide conjugates to target the epidermal growth factor receptor (EGFR) and its double mutant EGFR...
-
Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma
Lung adenocarcinoma (LUAD) is associated with a low survival rate at advanced stages. Although the development of targeted therapies has improved...
-
Identification of the causal mutation in early heading mutant of bread wheat (Triticum aestivum L.) using MutMap approach
In bread wheat ( Triticum aestivum L.), fine-tuning the heading time is essential to maximize grain yield. Photoperiod-1 ( Ppd-1 ) and VERNALIZATION 1 ( Vrn-1...
-
Phenotypic characterization of auxotrophic mutant of nontyphoidal Salmonella and determination of its cytotoxicity, tumor inhibiting cytokine gene expression in cell line models
An auxotrophic mutant of nontyphoidal Salmonella (NTS) strain ( Salmonella Oslo) was phenotypically characterized in this study. The characterization...
-
Histological, Cytological, and Ultrastructural Analysis of a Novel Sesame Mutant JQA Showing Wrinkled Leaf and Abort Anther
The leaf is the most important organ for photosynthesis; a moderately curly leaf is beneficial for improving the light energy utilization rate. Male...
-
Japanese medaka Olpax6.1 mutant as a potential model for spondylo-ocular syndrome
pax6 is a canonic master gene for eye formation. Knockout of pax6 affects the development of craniofacial skeleton and eye in mice. Whether pax6 ...
-
Function of Burkholderia pseudomallei RpoS and RpoN2 in bacterial invasion, intracellular survival, and multinucleated giant cell formation in mouse macrophage cell line
Melioidosis, a human infectious disease with a high mortality rate in many tropical countries, is caused by the pathogen Burkholderia pseudomallei (B....
-
Multiomics analysis revealed the mechanisms related to the enhancement of proliferation, metastasis and EGFR-TKI resistance in EGFR-mutant LUAD with ARID1A deficiency
IntroductionDysregulated ARID1A expression is frequently detected in lung adenocarcinoma (LUAD) and mediates significant changes in cancer behaviors...
-
Mutant kri1l causes abnormal retinal development via cell cycle arrest and apoptosis induction
Damage to the ribosome or an imbalance in protein biosynthesis can lead to some human diseases, such as diabetic retinopathy (DR) and other eye...
-
Photosynthetic characteristics and genetic map** of a new yellow leaf mutant crm1 in Brassica napus
Chlorophyll is one of the key factors for photosynthesis and plays an important role in plant growth and development. We previously isolated an EMS...
-
Substitution of arginine 219 by glycine compromises stability, dimerization, and catalytic activity in a G6PD mutant
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common enzymopathies in humans, present in approximately half a billion people...
-
Identification and functional analysis of a chromosome 2D fragment harboring TaFPF1 gene with the potential for yield improvement using a late heading wheat mutant
Key messageA chromosome fragment influencing wheat heading and grain size was identified using map** of m406 mutant. The study of TaFPF1 in this...
-
Protein-level mutant p53 reporters identify druggable rare precancerous clones in noncancerous tissues
Detecting and targeting precancerous cells in noncancerous tissues is a major challenge for cancer prevention. Massive stabilization of mutant p53...
-
Creation and gene expression analysis of a giant embryo rice mutant with high GABA content
Gamma-amino butyric acid (GABA) is a natural non-protein amino acid involved in stress, signal transmission, carbon and nitrogen balance, and other...
-
Transcriptome analysis of gene expression in the tomato leaf premature senescence mutant
Premature senescence of leaves can critically influence tomato yield and quality. In this study, the leaf premature senescence mutant MT318 was a...
-
Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas
BackgroundIDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of...
-
Two at once: simultaneous increased production of astaxanthin and mycosporines in a single batch culture using a Phaffia rhodozyma mutant strain
Phaffia rhodozyma is a basidiomycetous yeast characterized by its production of the carotenoid pigment astaxanthin, which holds high commercial value...
-
Design and investigation of interactions of novel peptide conjugates of purine and pyrimidine derivatives with EGFR and its mutant T790M/L858R: an in silico and laboratory study
Peptide-based therapeutics have been gaining attention due to their ability to actively target tumor cells. Additionally, several varieties of...
